期刊
CEREBRAL CORTEX
卷 33, 期 1, 页码 11-22出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhac049
关键词
auditory feedback; speech motor control; supramarginal gyrus; transcranial magnetic stimulation; hemisphere laterality
资金
- National Natural Science Foundation of China [82172528, 81772439, 81972147, 82102660, 61771461]
- Shenzhen Science and Technology Program [JCYJ20210324115810030]
- Guangdong Province Science and Technology Planning Project [2017A050501014]
- Guangzhou Science and Technology Programme [201604020115]
- Fundamental Research Funds for the Central Universities [20ykjc02]
- China Postdoctoral Science Foundation [2021M693684,2020M683104]
This study investigated the causal roles of the left and right supramarginal gyrus (SMG) in auditory feedback control of vocal production. Stimulation of both the left and right SMG led to decreased vocal compensations and reduced cortical P2 responses. No significant differences were found in the vocal and ERP responses when comparing stimulation over the left vs. right SMG, indicating a bilateral causal influence of the SMG on auditory feedback control.
The supramarginal gyrus (SMG) has been implicated in auditory-motor integration for vocal production. However, whether the SMG is bilaterally or unilaterally involved in auditory feedback control of vocal production in a causal manner remains unclear. The present event-related potential (ERP) study investigated the causal roles of the left and right SMG to auditory-vocal integration using neuronavigated continuous theta burst stimulation (c-TBS). Twenty-four young adults produced sustained vowel phonations and heard their voice unexpectedly pitch-shifted by +/- 200 cents after receiving active or sham c-TBS over the left or right SMG. As compared to sham stimulation, c-TBS over the left or right SMG led to significantly smaller vocal compensations for pitch perturbations that were accompanied by smaller cortical P2 responses. Moreover, no significant differences were found in the vocal and ERP responses when comparing active c-TBS over the left vs. right SMG. These findings provide neurobehavioral evidence for a causal influence of both the left and right SMG on auditory feedback control of vocal production. Decreased vocal compensations paralleled by reduced P2 responses following c-TBS over the bilateral SMG support their roles for auditory-motor transformation in a bottom-up manner: receiving auditory feedback information and mediating vocal compensations for feedback errors.
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