4.6 Article

Distinct roles for the anterior temporal lobe and angular gyrus in the spatiotemporal cortical semantic network

期刊

CEREBRAL CORTEX
卷 32, 期 20, 页码 4549-4564

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab501

关键词

connectivity modeling; dynamic causal modeling; EEG; MEG source estimation; semantic network; spatiotemporal dynamics

资金

  1. Cambridge University International Scholarship award by Cambridge Commonwealth, European and International Trust
  2. UK Medical Research Council [SUAG/046 G101400, SUAG/058 G101400]
  3. Medical Research Council [MC_UU_00005/18]

向作者/读者索取更多资源

This study explores the characteristics of a semantic hub through analyzing the spatiotemporal modulation of neural activity and connectivity. The results support the view that there is a single semantic hub, with the left anterior temporal lobe showing sustained modulation of neural activity by semantics and the connectivity between the anterior temporal lobe and the supramarginal/angular gyrus differing depending on the stage of semantic processing.
Semantic knowledge is supported by numerous brain regions, but the spatiotemporal configuration of the network that links these areas remains an open question. The hub-and-spokes model posits that a central semantic hub coordinates this network. In this study, we explored distinct aspects that define a semantic hub, as reflected in the spatiotemporal modulation of neural activity and connectivity by semantic variables, from the earliest stages of semantic processing. We used source-reconstructed electro/magnetoencephalography, and investigated the concreteness contrast across three tasks. In a whole-cortex analysis, the left anterior temporal lobe (ATL) was the only area that showed modulation of evoked brain activity from 100 ms post-stimulus. Furthermore, using Dynamic Causal Modeling of the evoked responses, we investigated effective connectivity amongst the candidate semantic hub regions, that is, left ATL, supramarginal/angular gyrus (SMG/AG), middle temporal gyrus, and inferior frontal gyrus. We found that models with a single semantic hub showed the highest Bayesian evidence, and the hub region was found to change from ATL (within 250 ms) to SMG/AG (within 450 ms) over time. Our results support a single semantic hub view, with ATL showing sustained modulation of neural activity by semantics, and both ATL and AG underlying connectivity depending on the stage of semantic processing.

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