期刊
CERAMICS INTERNATIONAL
卷 47, 期 20, 页码 29342-29354出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2021.07.101
关键词
Porous silicon nitride; Protective gelling agent; Porous structure; Nano-hydroxyapatite coating; Bioactivity
资金
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_0994]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
By modifying the direct foaming process with the introduction of protective gelling agent (PGA) combined with quench-freezing technique, porous Si3N4 substrates with improved stability and strength were prepared. The adhesion strength of the nHA coating was relatively low, but the pristine porous silicon nitride exhibited considerable bioactivity comparable to that with nHA coating.
Porous Si3N4 substrate for scaffold is prepared by the direct foaming process that is modified by introducing a protective gelling agent (PGA) combined with quench-freezing technique in this work. Nano-hydroxyapatite (nHA) is deposited onto the as-prepared substrate. The adhesion strength of the deposited nHA is evaluated with ultrasonic vibration method and the bioactivity of the pristine porous silicon nitride and that with nHA coating (nHA-coated Si3N4) are assessed by simulated body fluid (SBF) treatment along with in vitro cell culture experiments. The results indicate that compared with conventional direct foaming method, the introducing of PGA combined with quench-freezing significantly enhances the stability of foams and lowers the standard deviation of pore size distribution, leading to improved strength and reliability of the porous Si3N4 substrates. It is also found that the adhesion strength of the nHA coating is relatively low as shown by mass loss experiment with an ultrasonic cleaning device. The results of SBF treatment and in vitro cell culture experiment demonstrate that the pristine porous silicon nitride exhibits considerable bioactivity comparable to that with nHA coating.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据