期刊
CELLULOSE
卷 28, 期 18, 页码 11451-11463出版社
SPRINGER
DOI: 10.1007/s10570-021-04259-x
关键词
Pectin; Bacterial cellulose; Polypyrrole; Ibuprofen; Electrically controlled release
资金
- King Mongkut's University of Technology Thonburi under KMUTT Research Center of Excellence Project
- Thailand Science Research and Innovation (TSRI) Basic Research Fund: Fiscal year 2021 [64A306000039]
- National Taiwan University of Science and Technology, Taiwan
This study focused on electrically controlled transdermal drug delivery using pectin/bacteria cellulose hydrogel composites. The research showed that drug release was optimized at 30 wt% bacteria cellulose content, and could be increased to 78% under applied electrical potential. The hydrogel composites also exhibited remarkable antibacterial activity, making them valuable alternative materials for transdermal drug delivery.
Pectin/bacteria cellulose (BC) hydrogel composites with various BC contents have been fabricated for the purpose of electrically controlled transdermal drug delivery. A conductive polymer, polypyrrole, was successfully incorporated into the pectin/BC hydrogel composite as a host of drug encapsulation for controlled release under applied electric field. Ibuprofen as a model drug was studied for its release behavior based on the effects of matrix composition, pH stimulation, matrix mesh size, and applied electrical potential by using a modified Franz diffusion cell. The drug release was optimized at 30 wt% BC and increased with applying electrical potential. The highest amount of drug release was 78% which was obtained on a drug-loaded polypyrrole-incorporated composite under applied electrical potential at 7 V. The hydrogel composites also presented the remarkable benefit of antibacterial activity for gram-positive bacteria. Thus, the hydrogel composites are valuable alternative materials for transdermal drug delivery.
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