期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 42, 期 8, 页码 2571-2591出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-021-01153-9
关键词
Major depression; Blood-brain barrier (BBB); Neuroinflammatory; Cognitive function
资金
- National Natural Science Foundation of China [82001425]
Major depression is a complex psychological disease characterized by persistent depressed mood and cognitive impairment. Recent research has identified BBB disruption as a critical factor in the development of depression, contributing to neurological complications. Mechanisms and therapeutic targets for depression-related BBB dysfunction are still largely unknown.
Major depression represents a complex and prevalent psychological disease that is characterized by persistent depressed mood, impaired cognitive function and complicated pathophysiological and neuroendocrine alterations. Despite the multifactorial etiology of depression, one of the most recent factors to be identified as playing a critical role in the development of depression is blood-brain barrier (BBB) disruption. The occurrence of BBB integrity disruption contributes to the disturbance of brain homeostasis and leads to complications of neurological diseases, such as stroke, chronic neurodegenerative disorders, neuroinflammatory disorders. Recently, BBB associated tight junction disruption has been shown to implicate in the pathophysiology of depression and contribute to increased susceptibility to depression. However, the underlying mechanisms and importance of BBB damage in depression remains largely unknown. This review highlights how BBB disruption regulates the depression process and the possible molecular mechanisms involved in development of depression-induced BBB dysfunction. Moreover, insight on promising therapeutic targets for treatment of depression with associated BBB dysfunctions are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据