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Aldenor G. Santos et al.
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Tilman Flock et al.
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Atul Bhardwaj et al.
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Fabrizio Fierro et al.
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GPCRdb: the G protein-coupled receptor database - an introduction
C. Munk et al.
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Dean P. Staus et al.
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Ranjan V. Mannige et al.
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James A. R. Dalton et al.
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Xavier Deupi et al.
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Karl J. V. Nordstrom et al.
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Fabian Sievers et al.
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Jay P. Slack et al.
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Takanobu Sakurai et al.
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Anne Brockhoff et al.
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Jalview Version 2-a multiple sequence alignment editor and analysis workbench
Andrew M. Waterhouse et al.
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Cedrick D. Dotson et al.
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N Soranzo et al.
CURRENT BIOLOGY (2005)
The repertoire of G-protein-coupled receptors in fully sequenced genomes
R Fredriksson et al.
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KL Mueller et al.
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R Fredriksson et al.
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E Adler et al.
CELL (2000)