4.7 Review

Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Gastroprotective effects of irsogladine maleate on ethanol/hydrochloric acid induced gastric ulcers in mice

Seong Chun Kwon et al.

Summary: Irsogladine maleate (IM) demonstrated significant inhibitory effects on gastric ulcers induced by ethanol and hydrochloric acid, possibly mediated by nitric oxide, cAMP, endogenous prostaglandins, KATP channel opening, TRPV1 channel activation, and antioxidant properties.

KOREAN JOURNAL OF INTERNAL MEDICINE (2021)

Article Gastroenterology & Hepatology

A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity

Anoop Kumar et al.

Summary: The study demonstrated that DRA deficiency results in increased colonic paracellular permeability and decreased levels of tight junction/adherens junction proteins. Dysregulation of DRA may have potential implications for IBD pathogenesis by compromising intestinal epithelial barrier function.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Decreased Tumoral Expression of Colon-Specific Water Channel Aquaporin 8 Is Associated With Reduced Overall Survival in Colon Adenocarcinoma

Stephen J. O'Brien et al.

Summary: Using RNA-sequencing data, this study identified aquaporin 8 as a highly specific biomarker for overall survival in colon adenocarcinoma, with low expression being a risk factor for worse overall survival in patients with colon cancer.

DISEASES OF THE COLON & RECTUM (2021)

Article Gastroenterology & Hepatology

Inflammatory Bowel Disease in Patients with Congenital Chloride Diarrhoea

Lorenzo Norsa et al.

Summary: A significant proportion of patients with Congenital Chloride Diarrhoea develop Inflammatory Bowel Disease, which may require surgery for treatment failure or colon cancer.

JOURNAL OF CROHNS & COLITIS (2021)

Review Biochemistry & Molecular Biology

Gastrin and the Moderate Hypergastrinemias

Jens F. Rehfeld

Summary: Gastrin plays a critical role in regulating gastric acid secretion and fundic mucosal growth, with normal production and plasma concentrations being essential for early digestion. This review covers the biogenesis of gastrin in antral mucosa, its expression outside the antrum, molecular nature, concentration levels in serum, accurate measurement assays, and issues related to moderate hypergastrinemia due to H. pylori infections and PPI treatment. Accurate measurement of bioactive gastrin concentrations in plasma is crucial, along with the serious attention required for moderate hypergastrinemias as essential health concerns.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Cystic fibrosis

Michal Shteinberg et al.

LANCET (2021)

Article Oncology

Association study between KCNQ1 and KCNQ1OT1 genetic polymorphisms and gastric cancer susceptibility and survival in a Chinese Han population: a case-control study

Zhenyu Yang et al.

Summary: The study analyzed gene polymorphisms in KCNQ1 and KCNQ1OT1 and found their association with genetic susceptibility and survival in a Chinese Han population with gastric cancer. Specific genotypes were identified as independent predictors of GC susceptibility, while others independently predicted the survival of GC patients.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Gastroenterology & Hepatology

Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage

Andrea L. Matthis et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Article Microbiology

CFTR dysregulation drives active selection of the gut microbiome

Stacey M. Meeker et al.

PLOS PATHOGENS (2020)

Article Gastroenterology & Hepatology

An indisputable role of NHE8 in mucosal protection

Claudio Bernardazzi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Identification of the AQP8-miR-92a network associated with the aggressive traits of colorectal cancer

Hui Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Suppression of CLC-3 reduces the proliferation, invasion and migration of colorectal cancer through Wnt/β-catenin signaling pathway

Hailian Mu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

NHE1 Mediates 5-Fu Resistance in Gastric Cancer via STAT3 Signaling Pathway

Zhenni Sun et al.

ONCOTARGETS AND THERAPY (2020)

Article Medical Laboratory Technology

Prognostic value of serum aquaporin-1, aquaporin-3 and galectin-3 for young patients with colon cancer

Yanyan Hong et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2020)

Article Gastroenterology & Hepatology

KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This Might Be a Novel Marker and Therapeutic Option Targeting Potassium Channels

Christoph Suess et al.

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES (2020)

Review Microbiology

Autoimmune Gastritis and Gastric Microbiota

Laura Conti et al.

MICROORGANISMS (2020)

Article Gastroenterology & Hepatology

Leaky gut: mechanisms, measurement and clinical implications in humans

Michael Camilleri

Article Pharmacology & Pharmacy

Role of Aquaporin-3 in Intestinal Injury Induced by Sepsis

Yeke Zhu et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

Article Gastroenterology & Hepatology

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Hua Xu et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Biochemistry & Molecular Biology

Significance of aquaporins' expression in the prognosis of gastric cancer

Saroj Thapa et al.

BIOSCIENCE REPORTS (2018)

Article Cell Biology

Aggravated intestinal apoptosis by ClC-3 deletion is lethal to mice endotoxemia

Lin-Yan Huang et al.

CELL BIOLOGY INTERNATIONAL (2018)

Article Gastroenterology & Hepatology

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations

Denis Hadjiliadis et al.

GASTROENTEROLOGY (2018)

Article Pharmacology & Pharmacy

Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Xuelian Lei et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2018)

Article Medicine, Research & Experimental

SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis

Xiangming Ding et al.

LABORATORY INVESTIGATION (2018)

Article Gastroenterology & Hepatology

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

Younggeon Jin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Physiology

SLC9 Gene Family: Function, Expression, and Regulation

Hua Xu et al.

COMPREHENSIVE PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Role of CFTR in epithelial physiology

Vinciane Saint-Criq et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Biochemistry & Molecular Biology

Molecular and functional characterization of the endothelial ATP-sensitive potassium channel

Qadeer Aziz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Cell Biology

Na+/H+ exchanger NHE1 and NHE2 have opposite effects on migration velocity in rat gastric surface cells

Anja Paehler vor der Nolte et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

Review Medicine, General & Internal

Peptic ulcer disease

Angel Lanas et al.

LANCET (2017)

Article Multidisciplinary Sciences

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

Jay R. Thiagarajah et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Gastroenterology & Hepatology

Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D Mutation

Daniel Gelfond et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2017)

Article Multidisciplinary Sciences

Mechanism of down regulation of Na-H exchanger-2 in experimental colitis

Amal Ali Soleiman et al.

PLOS ONE (2017)

Article Gastroenterology & Hepatology

Hemorrhagic polyps formed like fundic gland polyps during long-term proton pump inhibitor administration

Tsutomu Takeda et al.

CLINICAL JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Xiao Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Review Biochemistry & Molecular Biology

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

Yangzom D. Bhutia et al.

BIOCHEMICAL JOURNAL (2016)

Article Biotechnology & Applied Microbiology

Expression, localization and possible functions of aquaporins 3 and 8 in rat digestive system

G. X. Zhao et al.

BIOTECHNIC & HISTOCHEMISTRY (2016)

Review Gastroenterology & Hepatology

Potassium Channelopathies and Gastrointestinal Ulceration

Jaeyong Han et al.

GUT AND LIVER (2016)

Review Biochemistry & Molecular Biology

Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines

Cui Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

CFTR is a tumor suppressor gene in murine and human intestinal cancer

B. L. N. Than et al.

ONCOGENE (2016)

Article Multidisciplinary Sciences

Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway

Nan-lin Xiang et al.

SCIENTIFIC REPORTS (2016)

Article Gastroenterology & Hepatology

Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations

Eitaro Aihara et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Loss of NHE8 expression impairs intestinal mucosal integrity

Aiping Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Review Physiology

Physiological Roles of Acid-Base Sensors

Lonny R. Levin et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 77 (2015)

Article Gastroenterology & Hepatology

Trastuzumab Inhibits Growth of HER2-Negative Gastric Cancer Cells Through Gastrin-Initialized CCKBR Signaling

Yan Cui et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

Review Gastroenterology & Hepatology

Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease-Associated Diarrhea

Shubha Priyamvada et al.

INFLAMMATORY BOWEL DISEASES (2015)

Article Biochemistry & Molecular Biology

Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis

Vazhaikkurichi M. Rajendran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Genetic Ablation of the ClC-2 Cl-Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion

Meghali P. Nighot et al.

PLOS ONE (2015)

Article Physiology

Carbachol-induced colonic mucus formation requires transport via NKCC1, K+ channels and CFTR

Jenny K. Gustafsson et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)

Article Pathology

Gastrointestinal Pathology in Juvenile and Adult CFTR-Knockout Ferrets

Xingshen Sun et al.

AMERICAN JOURNAL OF PATHOLOGY (2014)

Article Biochemistry & Molecular Biology

Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis

Guangxi Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Hydrogen Peroxide as a Damage Signal in Tissue Injury and Inflammation: Murderer, Mediator, or Messenger?

Albert van der Vliet et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2014)

Article Oncology

Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer

Jia Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)

Article Gastroenterology & Hepatology

Mucosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice

Seiichiro Fukuhara et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

The role of KCNQ1 in mouse and human gastrointestinal cancers

B. L. N. Than et al.

ONCOGENE (2014)

Article Biochemistry & Molecular Biology

ClC-3 Is an Intracellular Chloride/Proton Exchanger with Large Voltage-Dependent Nonlinear Capacitance

Raul E. Guzman et al.

ACS CHEMICAL NEUROSCIENCE (2013)

Article Cell Biology

Effect of NSAIDs on Na+/H+ exchanger activity in rat colonic crypts

Aliya C. Roginiel et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

Article Cell Biology

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Chang Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

Article Gastroenterology & Hepatology

Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice

Nhung Nguyen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Gastroenterology & Hepatology

NHE8 plays important roles in gastric mucosal protection

Hua Xu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

EGR1 is critical for gastrin-dependent upregulation of anion exchanger 2 in gastric cancer cells

Ting Wang et al.

FEBS JOURNAL (2013)

Article Gastroenterology & Hepatology

Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis

Prashant Nighot et al.

INFLAMMATORY BOWEL DISEASES (2013)

Article Biochemistry & Molecular Biology

The Epac1 Signaling Pathway Regulates Cl- Secretion via Modulation of Apical KCNN4c Channels in Diarrhea

Irshad Ali Sheikh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

The SLC4 family of bicarbonate (HCO3-) transporters

Michael F. Romero et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Review Pharmacology & Pharmacy

Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

Jane M. M. Natividad et al.

PHARMACOLOGICAL RESEARCH (2013)

Article Medicine, Research & Experimental

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

Tzyh-Chang Hwang et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2013)

Article Physiology

Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa

Julia Anna-Maria Eberle et al.

FRONTIERS IN PHYSIOLOGY (2013)

Article Gastroenterology & Hepatology

Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

Hua Xu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Article Gastroenterology & Hepatology

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

Hong-Bo Wang et al.

DIGESTIVE DISEASES AND SCIENCES (2012)

Article Gastroenterology & Hepatology

Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 Channels

Marcelo A. Catalan et al.

GASTROENTEROLOGY (2012)

Article Gastroenterology & Hepatology

Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis

William J. Sandborn et al.

GASTROENTEROLOGY (2012)

Editorial Material Gastroenterology & Hepatology

The elegance of the gastric mucosal barrier: designed by nature for nature

Kenneth E. L. McColl

Article Gastroenterology & Hepatology

Loss of downregulated in adenoma (DRA) impairs mucosal HCO3-secretion in murine ileocolonic inflammation

Fang Xiao et al.

INFLAMMATORY BOWEL DISEASES (2012)

Article Biochemistry & Molecular Biology

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain

Eliska Svastova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Physiology

NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts

Matyas Czepan et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)

Article Gastroenterology & Hepatology

Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa

Meghali Nighot et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

Article Cell Biology

Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway

Chunhui Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Editorial Material Gastroenterology & Hepatology

Gastric secretion

Mitchell L. Schubert

CURRENT OPINION IN GASTROENTEROLOGY (2011)

Article Pharmacology & Pharmacy

Diazoxide attenuates indomethacin-induced small intestinal damage in the rat

Alessandro Menozzi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Knockdown of aquaporin 3 is involved in intestinal barrier integrity impairment

Wenjie Zhang et al.

FEBS LETTERS (2011)

Article Genetics & Heredity

Update on SLC26A3 Mutations in Congenital Chloride Diarrhea

Satu Wedenoja et al.

HUMAN MUTATION (2011)

Article Gastroenterology & Hepatology

New Therapeutic Targets in Ulcerative Colitis: The Importance of Ion Transporters in the Human Colon

Klaudia Farkas et al.

INFLAMMATORY BOWEL DISEASES (2011)

Article Biochemistry & Molecular Biology

Trefoil Factor 2 Requires Na/H Exchanger 2 Activity to Enhance Mouse Gastric Epithelial Repair

Lin Xue et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Multidisciplinary Sciences

Genetics and pathogenesis of inflammatory bowel disease

Bernard Khor et al.

NATURE (2011)

Review Gastroenterology & Hepatology

Review article: the clinical management of congenital chloride diarrhoea

S. Wedenoja et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2010)

Article Gastroenterology & Hepatology

KCNN4 Gene Variant Is Associated With Ileal Crohn's Disease in the Australian and New Zealand Population

Lisa A. Simms et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction

Prashant K. Nighot et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Physiology

Chloride Channels: Often Enigmatic, Rarely Predictable

Charity Duran et al.

ANNUAL REVIEW OF PHYSIOLOGY (2010)

Article Medicine, Research & Experimental

Expression profile of multiple aquaporins in human gastric carcinoma and its clinical significance

Lizong Shen et al.

BIOMEDICINE & PHARMACOTHERAPY (2010)

Article Gastroenterology & Hepatology

Acid Suppression by Proton Pump Inhibitors Enhances Aquaporin-4 and KCNQ1 Expression in Gastric Fundic Parietal Cells in Mouse

Juntaro Matsuzaki et al.

DIGESTIVE DISEASES AND SCIENCES (2010)

Article Multidisciplinary Sciences

Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

Lie Di et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Pharmacology & Pharmacy

Volume-activated chloride channels contribute to cell-cycle-dependent regulation of HeLa cell migration

Jianwen Mao et al.

BIOCHEMICAL PHARMACOLOGY (2009)

Article Gastroenterology & Hepatology

Differential expression of aquaporin-4 in human gastric normal and cancer tissues

H. Xu et al.

GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE (2009)

Article Medicine, Research & Experimental

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

Mary Abigail S. Garcia et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Gastroenterology & Hepatology

Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function

Adam J. Moeser et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Gastroenterology & Hepatology

Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells

Erika C. Claud et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Gastroenterology & Hepatology

Localization, trafficking, and significance for acid secretion of parietal cell kir4.1 and KCNQ1 K+ channels

Marc-Andre Kaufhold et al.

GASTROENTEROLOGY (2008)

Review Gastroenterology & Hepatology

Gastric mucosal defense and cytoprotection: Bench to bedside

Loren Laine et al.

GASTROENTEROLOGY (2008)

Review Gastroenterology & Hepatology

Control of gastric acid secretion in health and disease

Mitchell L. Schubert et al.

GASTROENTEROLOGY (2008)

Review Cardiac & Cardiovascular Systems

Molecular biology of the myocardial Na+/H+ exchanger

Larry Fliegel

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)

Article Neurosciences

Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue

Tanja Maritzen et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Medicine, General & Internal

Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

Paul M. Quinton

LANCET (2008)

Article Gastroenterology & Hepatology

Effect of NHE1 antisense gene transfection on the biological behavior of SGC-7901 human gastric carcinoma cells

Hai-Feng Liu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis

Jay R. Thiagarajah et al.

Article Cell Biology

Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters

Patricio E. Morgan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Gastroenterology & Hepatology

Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis

Alexandra Zahn et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2007)

Article Biochemistry & Molecular Biology

ΔF508 mutation results in impaired gastric acid secretion

Shafik M. Sidani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Gastroenterology & Hepatology

Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone

Adam J. Moeser et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

Article Gastroenterology & Hepatology

Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and bicarbonate secretion

Hui Dong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Gastroenterology & Hepatology

Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine

Adam J. Moeser et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Gastroenterology & Hepatology

Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection

Maria Van der Sluis et al.

GASTROENTEROLOGY (2006)

Article Pathology

Inefficient chronic activation of parietal cells in Ae2a,b-/- mice

Sergio Recalde et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

Article Cell Biology

Gene expression profiling of gastrin target genes in parietal cells

RN Jain et al.

PHYSIOLOGICAL GENOMICS (2006)

Review Pharmacology & Pharmacy

The CIC-3Cl(-) channel in cell volume regulation, proliferation and apoptosis in vascular smooth muscle cells

YY Guan et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2006)

Review Pharmacology & Pharmacy

K+ channels as targets for specific immunomodulation

KG Chandy et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2004)

Review Physiology

The SLC26 gene family of multifunctional anion exchangers

DB Mount et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

Article Gastroenterology & Hepatology

Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells

J Lu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric

LR Gawenis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice

CM Elso et al.

HUMAN MOLECULAR GENETICS (2004)

Article Biochemistry & Molecular Biology

Membrane permeabilization by non-steroidal anti-inflammatory drugs

W Tomisato et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Review Cell Biology

Trefoil factors: Initiators of mucosal healing

D Taupin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Cell Biology

Distribution of ClC-2 chloride channel in rat and human epithelial tissues

J Lipecka et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

Article Cell Biology

Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract

G Calamita et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2001)

Article Gastroenterology & Hepatology

Differential expression and regulation of Na+/H+ exchanger isoforms in rabbit parietal and mucous cells

H Rossmann et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)

Article Cell Biology

Localization of ClC-2Cl- channels in rabbit gastric mucosa

AM Sherry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)

Article Cell Biology

IFN-γ downregulates expression of Na+/H+ exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells

F Rocha et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)

Article Gastroenterology & Hepatology

The cardiac K+ channel KCNQ1 is essential for gastric acid secretion

F Grahammer et al.

GASTROENTEROLOGY (2001)

Article Gastroenterology & Hepatology

Diazoxide, a KATP opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines

M Rahgozar et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2001)

Article Cell Biology

Expression of the chloride channel ClC-2 in the murine small intestine epithelium

K Gyömörey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)

Article Biochemistry & Molecular Biology

Up-regulation of the IKCa1 potassium channel during T-cell activation -: Molecular mechanism and functional consequences

S Ghanshani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Gastroenterology & Hepatology

Gastric acid secretion in aquaporin-4 knockout mice

KS Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)