T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

Article Multidisciplinary Sciences

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Lihong Liu et al.

NATURE (2021)

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Article Multidisciplinary Sciences

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Sandile Cele et al.

NATURE (2021)

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Article Multidisciplinary Sciences

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Delphine Planas et al.

NATURE (2021)

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Article Immunology

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients

Sunil Kumar Saini et al.

Summary: This study experimentally evaluated MHC class I-binding peptides covering the complete SARS-CoV-2 genome, revealing significant CD8(+) T cell recognition of SARS-CoV-2 epitopes in patients with COVID-19, coupled with strong activation features in these T cells. Compared to healthy individuals, patients with severe disease displayed larger populations of SARS-CoV-2-specific T cells.

SCIENCE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

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Article Cell Biology

Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

Alison Tarke et al.

Summary: The study showed that SARS-CoV-2 variants do not significantly disrupt total T cell reactivity, although decreases in response frequency of 10%-22% were observed under certain assay/VOC combinations. This underscores the importance of actively monitoring T cell responses in the context of SARS-CoV-2 evolution.

CELL REPORTS MEDICINE (2021)

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Article Cell Biology

Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform

Ahmed Abdul Quadeer et al.

Summary: This study provides a unified description and meta-analysis of SARS-CoV-2 T cell epitopes from recovered individuals, showing a broad diversity of epitopes largely unaffected by current variants. A set of 20 immunoprevalent epitopes inducing T cell responses in multiple cohorts have been identified. This information can guide immunological studies related to vaccines and diagnostics.

CELL REPORTS MEDICINE (2021)

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Article Cell Biology

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

Alison Tarke et al.

Summary: By studying T cell responses in 99 convalescent COVID-19 cases, we identified various HLA-restricted epitopes derived from SARS-CoV-2 and observed distinct patterns of immunodominance. The epitopes were combined into megapools to facilitate the identification and quantification of virus-specific CD4(+) and CD8(+) T cells.

CELL REPORTS MEDICINE (2021)

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T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

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