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Article
Multidisciplinary Sciences
Yang Liu et al.
Summary: The B.1.1.7 variant (Alpha) of SARS-CoV-2 emerged in the UK in the summer of 2020, with 19 mutations including N501Y which is a major determinant of increased transmission. The N501Y substitution increased viral transmission by enhancing the spike protein's affinity for cellular receptors, making it an adaptive spike mutation of concern.
Article
Multidisciplinary Sciences
Jessica A. Plante et al.
Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.
Letter
Immunology
Pai Peng et al.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Microbiology
Zhuoming Liu et al.
Summary: The study found that antibodies targeting the SARS-CoV-2 spike protein have escape mutations, different monoclonal antibodies have unique resistance profiles, some mutants are resistant to multiple antibodies while some variants can escape neutralization by convalescent sera. Comparing antibody-mediated mutations with circulating SARS-CoV-2 sequences revealed substitutions that may weaken neutralizing immune responses in some individuals, warranting further investigation.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Lihong Liu et al.
Article
Medicine, General & Internal
Juanjie Tang et al.
Summary: This study highlights the differences in antibody affinity maturation between individuals with prior COVID-19 infection and naive individuals post mRNA vaccination. Higher neutralizing antibodies were observed in convalescent individuals compared to naive individuals, along with differences in antibody binding and affinity. Additionally, males showed significantly higher antibody affinity against SARS-CoV-2 prefusion spike compared to females among the naive participants. Further research is needed to determine the role of antibody affinity in protection against SARS-CoV-2 and its variants.
Article
Multidisciplinary Sciences
Delphine Planas et al.
Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.
Review
Immunology
Hyunjhung Jhun et al.
Summary: As of September 21, 2021, over 228 million cases of COVID-19 have been reported worldwide, resulting in over 4 million deaths. The predominant circulating variants of concern are alpha, beta, gamma, and delta, originating from different countries like the UK, South Africa, Brazil/Japan, and India, respectively. These variants exhibit unique mutations in the spike gene, which may impact their infectivity and pathogenicity.
Article
Biochemistry & Molecular Biology
Jie Hu et al.
