Cut out that YAPping: Mechanisms to reduce scar formation

Article Cell & Tissue Engineering

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

Shamik Mascharak et al.

Summary: In this study, we investigated the molecular events driving skin wound cells toward scarring or regenerative fates. By integrating data from single-cell RNA sequencing, proteomics, and tissue analysis, we revealed the molecular trajectories of fibrosis and regeneration during wound healing. Disrupting YAP mechanotransduction was found to activate Trps1 and Wnt signaling in fibroblasts, leading to regenerative repair. Our findings provide a multi-omic map of wound regeneration and have therapeutic implications for pathologic fibroses.

CELL STEM CELL (2022)

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Article Multidisciplinary Sciences

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

Shamik Mascharak et al.

Summary: This study identified a dermal ENF subpopulation that activates Engrailed-1 expression through mechanical tension, promoting skin tissue regeneration. Blocking mechanotransduction signaling can stimulate ENF-mediated wound regeneration, leading to recovery of skin appendages and mechanical strength.

SCIENCE (2021)

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Article Endocrinology & Metabolism