Cut out that YAPping: Mechanisms to reduce scar formation

Tissue repair in adult mammals lacks the regenerative ability of many tissues in other adult organisms like axolotl and newts. In this issue of Cell Stem Cell, Mascharak et al. use multi-omics approaches to identify an essential role for the transcription factor Trps1 in Yap-inhibited fibroblasts' tissue regenerative responses in murine skin.

Automated summary

In this study, scientists used multi-omics approaches to identify the essential role of the transcription factor Trps1 in Yap-inhibited fibroblasts' tissue regenerative responses in murine skin, providing new insights into the mechanisms underlying the limited tissue repair ability of adult mammals.