期刊
CELL STEM CELL
卷 29, 期 2, 页码 232-+出版社
CELL PRESS
DOI: 10.1016/j.stem.2021.12.009
关键词
-
资金
- National Institutes of Health [HL157948, HL069438, DK056638, HL116340]
This study reveals that the microbiota regulates hematopoietic stem cells (HSCs) self-renewal and differentiation by modulating local iron availability in the bone marrow. Microbiota depletion enhances HSC self-renewal but compromises differentiation under stress conditions. The interplay between the microbiota, macrophages, and iron is essential for regulating critical HSC fate decisions.
Host microbiota crosstalk is essential for the production and functional modulation of blood-cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells (HSCs) is unclear. Here, we show that the microbiota regulates HSC self-renewal and differentiation under stress conditions by modulating local iron availability in the bone marrow (BM). In microbiota-depleted mice, HSC self-renewal was enhanced during regeneration, while the commitment toward differentiation was dramatically compromised. Mechanistically, microbiota depletion selectively impaired the recycling of red blood cells (RBCs) by BM macrophages, resulting in reduced local iron levels without affecting systemic iron homeostasis. Limiting iron availability in food (in vivo) or in culture (ex vivo), or by CD169(+) macrophage depletion, enhanced HSC self-renewal and expansion. These results reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
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