期刊
CELL STEM CELL
卷 28, 期 10, 页码 1690-1707出版社
CELL PRESS
DOI: 10.1016/j.stem.2021.09.001
关键词
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资金
- Canadian Institutes of Health Research [PJT-148816, FDN-375597, FDN-159908]
- Canada Foundation for Innovation (CFI)
- Ontario Research Fund (ORF) [36050, 38861, 38430, 36349]
- Canadian Foundation for Innovation
- BC Knowledge Development Fund [38395]
- Heart and Stroke Foundation of Canada [G-19-0026541]
- Fondation pour la Recherche Medicale (FRM) [40248]
- European Molecular Biology Organization (EMBO) [ALTF 115-2016]
- Association Francaise contre les Myopathies (AFM) [22576]
- Michael Smith Foundation for Health Research (MSFHR) [18351]
MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and regeneration of most tissues. They can differentiate along multiple connective lineages, but unlike most other stem/progenitor cells, they carry out various other functions while maintaining their developmental potential. MSCs function as damage sensors, respond to injury by fostering regeneration through secretion of trophic factors as well as extracellular matrix (ECM) molecules, and contribute to fibrotic reparative processes when regeneration fails. Tissue-specific MSC identity, fate(s), and function(s) are being resolved through fate mapping coupled with single cell omics,providing unparalleled insights into the secret lives of tissue-resident MSCs.
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