期刊
CELL PROLIFERATION
卷 55, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/cpr.13141
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类别
资金
- National Key Research and Development Program of China, Stem Cell and Translational Research [2018YFA0107203, 2017YFA0105501, 2018YFA0108400, 2018YFE0204400]
- National Natural Science Foundation of China [31771616, 81730005, 81970109]
- Key Scientific and Technological Projects of Guangdong Province [2019B020234001, 2019B020235002, 2019B020236004]
- Key Scientific and Technological Program of Guangzhou City [201803040011]
- Chinese Academy of Sciences [XDA16040501, XDA16040502, XDA16040504]
Mesenchymal stem cells (MSCs) have potential for cell therapy and tissue regeneration due to their properties, but their heterogeneity poses challenges. The "Human Mesenchymal Stem Cells" guidelines provide standards for quality control and technical specifications, aiming to accelerate the international standardization of MSCs for clinical development and therapeutic applications.
Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self-renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. 'Human Mesenchymal Stem Cells' is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.
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