期刊
CELL METABOLISM
卷 34, 期 1, 页码 11-20出版社
CELL PRESS
DOI: 10.1016/j.cmet.2021.12.012
关键词
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资金
- National Institutes of Health [DK56341, DK20579, UL1TR002345, RC2-DK118620, R01-DK55758, R01-DK099110]
- Academy of Finland
- Merck
- Novo Nordisk
- Sigrid Juselius Foundation
The accumulation of excessive body fat can lead to type 2 diabetes, and the risk of type 2 diabetes increases with an increase in body mass index. The global increase in obesity has therefore resulted in a corresponding increase in the prevalence of type 2 diabetes. The mechanisms linking obesity and type 2 diabetes involve complex changes in b cell function, adipose tissue biology, and multi-organ insulin resistance, which can be improved or even normalized through weight loss.
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in b cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.
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