期刊
CELL HOST & MICROBE
卷 30, 期 1, 页码 97-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2021.12.004
关键词
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资金
- Ministere de l'Economie et de l'Innovation du Quebec, Programme de soutien aux organismes de recherche et d'innovation
- Fondation du CHUM
- CIHR foundation grant [352417]
- CIHR [177958]
- Exceptional Fund COVID-19 from the Canada Foundation for Innovation (CFI) [41027]
- Sentinelle COVID Quebec network
- CIHR COVID-19 rapid response grant [OV3 170632]
- CIHR stream 1 SARS-CoV-2 Variant Research
- Canada Research Chair on Retroviral Entry [RCHS0235 950-232424]
- FRQS Junior 1 salary award
- FRQS PhD fellowship
- CIHR PhD fellowship
- Department of Microbiologie, Infectiologie et Immunology of Universite de Montreal
- MITACS Accele ration postdoctoral fellowships
- Public Health Agency of Canada, through the Vaccine Surveillance Reference group
- Public Health Agency of Canada through the COVID19 Immunity Task Force
The study found that extending the interval between doses to 16 weeks significantly increased humoral responses in non-infected individuals, reaching similar levels as previously infected individuals. Compared to a shorter interval, a longer interval between vaccine doses resulted in stronger immune responses.
The standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered three weeks apart. However, some public health authorities spaced these doses, raising questions about efficacy. We analyzed longitudinal humoral responses against the D614G strain and variants of concern for SARS-CoV-2 in a cohort of SARS-CoV-2-naive and previously infected individuals who received the BNT162b2 mRNA vaccine with sixteen weeks between doses. While administering a second dose to previously infected individuals did not significantly improve humoral responses, these responses significantly increased in naive individuals after a 16-week spaced second dose, achieving similar levels as in previously infected individuals. Comparing these responses to those elicited in individuals receiving a short (4-week) dose interval showed that a 16-week interval induced more robust responses among naive vaccinees. These findings suggest that a longer interval between vaccine doses does not compromise efficacy and may allow greater flexibility in vaccine administration.
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