期刊
CELL HOST & MICROBE
卷 30, 期 3, 页码 329-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2022.01.001
关键词
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资金
- National Key Research and Development Program of China [2018YFA0900400]
- Leading Talents of the Ten Thousand Talents Program
- National Key R&D Program of China [2018YFC1314600]
- Na-tional Natural Science Foundation of China [81571325, 81401117]
- Medical Science Advancement Program of Wuhan University [TFLC2018001]
- Shenzhen Institute of Synthetic Biology Scientific Research Program [HSY89901038]
Testosterone deficiency can lead to depressive symptoms, and gut microbes expressing 3β-HSD may be associated with depressive symptoms caused by testosterone degradation.
Testosterone deficiency can lead to depressive symptoms in humans; however, the causes of this deficiency are incompletely understood. Here, we isolated Mycobacterium neoaurum from the fecal samples of testosterone-deficient patients with depression and showed that this strain could degrade testosterone in vitro. Furthermore, gavaging rats with M. neoaurum reduced their serum and brain testosterone levels and induced depression-like behaviors. We identified the gene encoding 38-hydroxysteroid dehydrogenase (3 beta-HSD) as the enzyme causing testosterone degradation. Introducing 3 beta-HSD into Escherichia coli enhanced its ability to degrade testosterone. Gavaging rats with 3 beta-HSD-producing E. coli reduced their serum and brain testosterone levels and caused depression-like behaviors. Finally, compared with 16.67% of participants without depression, 42.99% (46/107) of the fecal samples of patients with depression harbored 3 beta-HSD, and 60.87% (28/46) of these fecal samples expressed 3 beta-HSD. These results suggest that 3 beta-HSD expressed by gut microbes may be associated with depressive symptoms due to testosterone degradation.
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