期刊
CELL HOST & MICROBE
卷 29, 期 12, 页码 1802-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2021.11.003
关键词
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资金
- IN-CONTROL CVON grant [CVON2012-03, CVON2018-27]
- European Research Council (ERC) [101001678]
- NWO VICI grant [VI.C.202.022]
- Noaber Foundation, Lunteren, the Netherlands
- ERC [715772]
- NWO-VIDI [016.178.056]
- NWO Gravitation [024.004.017]
- ZonMw Memorabel grant [733050814]
- NWO Spinoza Prize SPI [92-266]
- FP7/2007-2013/ERC advanced grant [2012-322698]
- University of Groningen Investment Agenda Grant Personalized Health
- Netherlands Organ-on-Chip Initiative, an NWO Gravitation project - Ministry of Education, Culture and Science of the Government of the Netherlands [024.003.001]
- China Scholarship Council [CSC201904910478, CSC201708320268]
- University Medical Center Groningen [CSC201708320268]
- Foundation de Cock-Hadders grant [20:20-13]
- University Medical Center Gronin-gen
The study found correlations between genetic variations in gut microbiota and host bile acid metabolism, highlighting the potential of lifestyle interventions in regulating bile acid metabolism through targeting gut microbiota.
Bile acids (BAs) facilitate intestinal fat absorption and act as important signaling molecules in host-gut micro biota crosstalk. BA-metabolizing pathways in the microbial community have been identified, but it remains largely unknown how the highly variable genomes of gut bacteria interact with host BA metabolism. We characterized 8,282 structural variants (SVs) of 55 bacterial species in the gut microbiomes of 1,437 individuals from two cohorts and performed a systematic association study with 39 plasma BA parameters. Both variations in SV-based continuous genetic makeup and discrete clusters showed correlations with BA metabolism. Metagenome-wide association analysis identified 809 replicable associations between bacterial SVs and BAs and SV regulators that mediate the effects of lifestyle factors on BA metabolism. This is the largest microbial genetic association analysis to demonstrate the impact of bacterial SVs on human BA composition, and it highlights the potential of targeting gut microbiota to regulate BA metabolism through lifestyle intervention.
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