期刊
CELL AND TISSUE RESEARCH
卷 387, 期 3, 页码 493-498出版社
SPRINGER
DOI: 10.1007/s00441-021-03560-2
关键词
Thrombin; PAR1; Blood brain barrier; Neurovascular unit; Organ-on-chips; Sensors; Human relevant in vitro models
类别
资金
- Azrieli Foundation
- Israel Science Foundation [2248/19]
- ERC SweetBrain [851765]
- Israel Ministry of Science and Technology [3-17351]
- Aufzien Family Center for the Prevention and Treatment of Parkinson's Disease
- German Research Foundation (DFG) [EXC 1086]
- Federal Ministry of Economics, Science and Arts of Baden-Wurttemberg within the sustainability program for projects of the excellence initiative II
- Freiburg Institute for Advanced Studies (FRIAS)
- German Israeli Foundation [GIF G-1317-418.13/2015]
- TEVA'
- Zimin
- European Research Council (ERC) [851765] Funding Source: European Research Council (ERC)
Blood coagulation factors can enter the brain under pathological conditions, affecting neural functions. Limitations in current experimental and clinical approaches hinder a profound understanding of neuro-coagulation mechanisms.
Blood coagulation factors can enter the brain under pathological conditions that affect the blood-brain interface. Besides their contribution to pathological brain states, such as neural hyperexcitability, neurodegeneration, and scar formation, coagulation factors have been linked to several physiological brain functions. It is for example well established that the coagulation factor thrombin modulates synaptic plasticity; it affects neural excitability and induces epileptic seizures via activation of protease-activated receptors in the brain. However, major limitations of current experimental and clinical approaches have prevented us from obtaining a profound mechanistic understanding of neuro-coagulation in health and disease. Here, we present how novel human relevant models, i.e., Organ-on-Chips equipped with advanced sensors, can help overcoming some of the limitations in the field, thus providing a perspective toward a better understanding of neuro-coagulation in brain homeostasis.
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