期刊
CELL
卷 184, 期 26, 页码 6262-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2021.11.031
关键词
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资金
- Hu-man Tumor Atlas Network [U2CCA233291, R01CA97386, R35CA197570, P50CA236733, R01DK103831, K07CA122451, T32LM012412, DK123489, U01CA215798, F31DK127687, HHSN261100039, HHSN261201500003I, VA IBX000930]
- DOD [CA160479, DK101332]
- Cancer UK [29075, P30CA068485]
- TPSR [U24DK059637]
- CHTN [UM1CA183727]
- REDCap [UL1TR000445]
- DHSR
- VAN-TAGE
- Nicholas Tierney GI Cancer Memorial Fund
Colorectal cancers originate from different precursor polyps, with factors related to stem cell expansion and cell differentiation playing key roles in tumor development; changes in the immune environment can also lead to mutations in tumor cells.
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights when analyzed at high resolution. We present a single-cell transcriptomic and imaging atlas of the two most common human colorectal polyps, conventional adenomas and serrated polyps, and their resulting CRC counterparts. Integrative analysis of 128 datasets from 62 participants reveals adenomas arise from WNT-driven expansion of stem cells, while serrated polyps derive from differentiated cells through gastric metaplasia. Metaplasia-associated damage is coupled to a cytotoxic immune microenvironment preceding hypermutation, driven partly by antigen-presentation differences associated with tumor cell-differentiation status. Microsatellite unstable CRCs contain distinct non-metaplastic regions where tumor cells acquire stem cell properties and cytotoxic immune cells are depleted. Our multi-omic atlas provides insights into malignant progression of colorectal polyps and their microenvironment, serving as a framework for precision surveillance and prevention of CRC.
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