期刊
CELL
卷 185, 期 5, 页码 847-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2022.01.015
关键词
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资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Department of Health and Human Services [75N93021C00016, 75N93019C00065]
- Clinical and Experimental Immunology Course at the University of Genoa, Italy
T cell responses induced by different vaccine platforms cross-recognize early SARS-CoV-2 variants, while memory B cells and neutralizing antibodies show significant decreases. The majority of memory T cell responses are preserved against variants, with lower recognition of Omicron by memory B cells.
We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. T cell responses to early variants were preserved across vaccine platforms. By contrast, significant overall decreases were observed for memory B cells and neutralizing antibodies. In subjects similar to 6 months post-vaccination, 90% (CD4(+)) and 87% (CD8(+)) of memory T cell responses were preserved against variants on average by AIM assay, and 84% (CD4(+)) and 85% (CD8(+)) preserved against Omicron. Omicron RBD memory B cell recognition was substantially reduced to 42% compared with other variants. T cell epitope repertoire analysis revealed a median of 11 and 10 spike epitopes recognized by CD4(+) and CD8(+) T cells, with average preservation > 80% for Omicron. Functional preservation of the majority of T cell responses may play an important role as a second-level defense against diverse variants.
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