期刊
CELL
卷 184, 期 24, 页码 5916-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2021.10.015
关键词
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资金
- Autism CRC under Australian Government's Cooperative Research Centre Program
- Autism CRC
- Centre of Research Excellence Grant from the Australian National Health and Medical Research Council [1078102]
- Australian National Health and Medical Research Council [1103418, 1127440, 1078901, 1173790, 1113400, 1077966, 1173896, 10787561]
- Australian Research Council [FT200100837, FL180100072]
- University of Queensland
- Mater Research and the Mater Foundation
- Australian Government
- Australian Research Council [FT200100837] Funding Source: Australian Research Council
- National Health and Medical Research Council of Australia [1173896, 1103418, 1127440] Funding Source: NHMRC
The study found negligible direct associations between ASD diagnosis and the gut microbiome, but suggested that ASD-related restricted interests may be linked to diet, microbial taxonomic diversity, and stool consistency. The dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency, cautioning against claims that the microbiome has a driving role in ASD.
There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way. We performed a large autism stool metagenomics study (n = 247) based on participants from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project. We found negligible direct associations between ASD diagnosis and the gut microbiome. Instead, our data support a model whereby ASD-related restricted interests are associated with less-diverse diet, and in turn reduced microbial taxonomic diversity and looser stool consistency. In contrast to ASD diagnosis, our dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency. Overall, microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD.
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