Potential Cardiotoxic Effects of Remdesivir on Cardiovascular System: A Literature Review

Article Medicine, Research & Experimental

Risk Assessment of Drug-Induced Long QT Syndrome for Some COVID-19 Repurposed Drugs

Veronique Michaud et al.

Summary: The risk-benefit ratio for repurposed drugs to treat COVID-19 is complex, with high or moderate risk of drug-induced LQTS for most medications. Monitoring of QT interval is recommended when using certain COVID-19 repurposed drugs.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

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Article Chemistry, Medicinal

Cardiac Events Potentially Associated to Remdesivir: An Analysis from the European Spontaneous Adverse Event Reporting System

Concetta Rafaniello et al.

Summary: This study analyzed the adverse cardiac events associated with remdesivir and found that 30.3% of the cases had fatal outcomes, with some cases involving other drugs for cardiovascular disorders simultaneously.

PHARMACEUTICALS (2021)

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Article Urology & Nephrology

Hypokalemia in Patients with COVID-19

Gaetano Alfano et al.

Summary: Hypokalemia is a common disorder in patients with COVID-19, with a prevalence of 41%. Female sex and diuretic therapy were identified as risk factors for low serum potassium levels. Hypokalemia was not associated with ICU transfer and death in this cohort of patients.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2021)

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Letter Pediatrics

Severe sinus bradycardia associated with Remdesivir in a child with severe SARS-CoV-2 infection

Maria Isabel Sanchez-Codez et al.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Letter Virology

Remdesivir might induce changes in electrocardiogram beyond bradycardia in patients with coronavirus disease 2019-The pilot study

Petra Bistrovic et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Infectious Diseases

Sinus Bradycardia in a Pediatric Patient Treated With Remdesivir for Acute Coronavirus Disease 2019: A Case Report and a Review of the Literature

Eric J. Chow et al.

Summary: This article describes a case of sinus bradycardia associated with Remdesivir therapy in a pediatric patient with severe COVID-19.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2021)

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Article Cardiac & Cardiovascular Systems

Complete heart block associated with Remdesivir in COVID-19: a case report

Vijairam Selvaraj et al.

Summary: In this case report, a 72-year-old male with COVID-19 developed transient complete atrioventricular block and bradycardia after initiating treatment with Remdesivir. Close cardiac monitoring is essential for patients on Remdesivir therapy, as discontinuation of the medication can lead to resolution of cardiac disturbances.

EUROPEAN HEART JOURNAL-CASE REPORTS (2021)

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Review Cardiac & Cardiovascular Systems

Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review

Fotios Barkas et al.

Summary: Using remdesivir in treating COVID-19 patients may lead to cardiac side effects, such as bradycardia. Physicians should be aware of this potential adverse event when administering remdesivir.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2021)

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Article Cardiac & Cardiovascular Systems