Rel-driven monocyte-derived macrophages push the pressured heart over the edge

Article Cardiac & Cardiovascular Systems

Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury

Shi-Hao Ni et al.

Summary: This study investigates the heterogeneity of cardiac macrophages in mice with transverse aortic constriction (TAC) and identifies a subset of macrophages associated with heart injury. The findings suggest that bone marrow-derived, Rel-mediated CD72(hi) macrophages play a pro-inflammatory role in inducing cardiac injury and could be a potential therapeutic target for cardiovascular diseases.

CARDIOVASCULAR RESEARCH (2022)

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Article Immunology

Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress

Rysa Zaman et al.

Summary: This study highlights the crucial role of resident macrophages in the adaptation of the heart to hypertension, with insulin-like growth factor-1 produced by these macrophages playing a key role in promoting cardiomyocyte growth and cardiac mass increase.

IMMUNITY (2021)

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Article Multidisciplinary Sciences

Cardiac macrophage subsets differentially regulate lymphatic network remodeling during pressure overload

Mathilde Bizou et al.

Summary: The study revealed that in the process of cardiac hypertrophy and failure, there is remodeling of lymphatic vessels and reduced lymphatic efficiency; the number of lymphatic endothelial cells in failing hearts is positively correlated with cardiac function and a subset of cardiac macrophages; macrophages identified by LYVE-1 play a key role in promoting lymphangiogenesis.

SCIENTIFIC REPORTS (2021)

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Article Cardiac & Cardiovascular Systems