4.7 Article

Remdesivir induces persistent mitochondrial and structural damage in human induced pluripotent stem cell-derived cardiomyocytes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

Yili Xu et al.

Summary: Remdesivir is the first FDA-approved antiviral for COVID-19 treatment, with broad-spectrum activity against various coronaviruses. Studies have shown low off-target toxicity in cellular assays, indicating a favorable safety profile.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Article Medicine, General & Internal

Repurposed Antiviral Drugs for Covid-19-Interim WHO Solidarity Trial Results

Summary: The authors of the study reported the interim results of using four repurposed antiviral drugs (remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a) in hospitalized COVID-19 patients. The study showed that these drug regimens had little or no effect on overall mortality, initiation of ventilation, and duration of hospital stay.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Infectious Diseases

Serious bradycardia and remdesivir for coronavirus 2019 (COVID-19): a new safety concerns

Anthony Touafchia et al.

Summary: The study found that the use of remdesivir in COVID-19 patients is significantly associated with an increased risk of reporting bradycardia, with most cases being serious and some resulting in fatalities. Compared to other medications, the use of remdesivir showed a higher risk of reporting bradycardia.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Review Physiology

Cell surface markers for immunophenotyping human pluripotent stem cell-derived cardiomyocytes

Kenneth R. Boheler et al.

Summary: Research shows that disparities among differentiation protocols and time of cultivation lead to mixed cultures of cardiac cells at various developmental stages, originating from differences in differentiation schemes and reprogramming. Immunophenotyping coupled with live cell sorting is a reliable method to overcome cell population heterogeneity.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2021)

Article Medicine, General & Internal

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

Dominic Wichmann et al.

ANNALS OF INTERNAL MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Potential Effects of Coronaviruses on the Cardiovascular System A Review

Mohammad Madjid et al.

JAMA CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Shaobo Shi et al.

JAMA CARDIOLOGY (2020)

Article Medicine, General & Internal

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

Jason D. Goldman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19

Sarah C. J. Jorgensen et al.

PHARMACOTHERAPY (2020)

Article Critical Care Medicine

Why COVID-19 Silent Hypoxemia Is Baffling to Physicians

Martin J. Tobin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Editorial Material Pharmacology & Pharmacy

Direct SARS-CoV-2 infection of the heart potentiates the cardiovascular sequelae of COVID-19

Rajendran J. C. Bose et al.

DRUG DISCOVERY TODAY (2020)

Article Medicine, General & Internal

The association between cardiac injury and outcomes in hospitalized patients with COVID-19

Shahrokh Karbalai Saleh et al.

INTERNAL AND EMERGENCY MEDICINE (2020)

Article Medicine, General & Internal

Association Between Hypoxemia and Mortality in Patients With COVID-19

Jiang Xie et al.

MAYO CLINIC PROCEEDINGS (2020)

Article Cardiac & Cardiovascular Systems

SARS-CoV-2 infects and induces cytotoxic effacts in human cardiomyocytes

Denisa Bojkova et al.

CARDIOVASCULAR RESEARCH (2020)

Article Multidisciplinary Sciences

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

Brandi N. Williamson et al.

NATURE (2020)

Article Cardiac & Cardiovascular Systems

Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury

Chun-Ka Wong et al.

CIRCULATION JOURNAL (2020)

Article Medicine, General & Internal

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

Christoph D. Spinner et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Immunology

Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection

Radha Gopal et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Pharmacology & Pharmacy

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

Sawittree Sahakijpijarn et al.

PHARMACEUTICS (2020)

Review Cell Biology

Cardiovascular Manifestations of COVID-19 Infection

Ajit Magadum et al.

Article Cell Biology

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection

Arun Sharma et al.

CELL REPORTS MEDICINE (2020)

Article Endocrinology & Metabolism

Cardiovascular disease and COVID-19

Manish Bansal

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Article Cardiac & Cardiovascular Systems

Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing

Gary Gintant et al.

CIRCULATION RESEARCH (2019)

Article Cell & Tissue Engineering

Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells

Xiulan Yang et al.

STEM CELL REPORTS (2019)

Review Pharmacology & Pharmacy

Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems

Tarek Magdy et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Microbiology

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

Joy Y. Feng et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Article Cardiac & Cardiovascular Systems

Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes

Natalie Weber et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics and mitochondrial quality control

Hong-Min Ni et al.

REDOX BIOLOGY (2015)

Review Medicine, General & Internal

Mitochondrial Dynamics - Mitochondrial Fission and Fusion in Human Diseases

Stephen L. Archer

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Pharmacology & Pharmacy

Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition

Nadezda Apostolova et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

Article Cell Biology

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

E Smirnova et al.

MOLECULAR BIOLOGY OF THE CELL (2001)