4.7 Editorial Material

The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect

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Review Endocrinology & Metabolism

The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials

Thinzar Min et al.

Summary: GLP-1 based therapy is a well-established treatment for type 2 diabetes, while GIP was previously thought to have no potential as a glucose-lowering therapy. However, recent evidence shows that co-infusion of GLP-1 and GIP has a synergistic effect. Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown promising glucose-lowering and weight loss effects in pre-clinical and phase 1 and 2 trials.

DIABETES THERAPY (2021)

Article Medicine, General & Internal

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

Julio Rosenstock et al.

Summary: Tirzepatide demonstrated significant improvements in glycemic control and body weight without increasing the risk of hypoglycemia. The safety profile was consistent with GLP-1 receptor agonists, suggesting a potential monotherapy use for the treatment of type 2 diabetes.

LANCET (2021)

Article Medicine, General & Internal

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

Juan P. Frias et al.

Summary: The study showed that Tirzepatide was both noninferior and superior to Semaglutide in terms of the mean change in glycated hemoglobin levels for patients with type 2 diabetes over 40 weeks. Additionally, reductions in body weight were greater with Tirzepatide compared to Semaglutide, with similar rates of gastrointestinal adverse events reported in both groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Francis S. Willard et al.

JCI INSIGHT (2020)

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Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease

T Nyström et al.

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