期刊
CARBOHYDRATE POLYMERS
卷 276, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118810
关键词
Hyaluronan; Coordination; Cisplatin; Indocyanine green; Nanoprodrug
资金
- National Natural Science Foundation of China [82073309, 52103185]
- Key Research and Development Program of Shaanxi Province of China [2020SF-033, 2020GY-290]
- Foundation Project of The First Affiliated Hospital of Xi'an Jiaotong University [2019ZYTS-15]
- Wu Jieping Medical Foundation [320.6750.2020-01-15, 320.6750.2021-16-11]
This study developed a multifunctional coordination nanoprodrug HBCI based on unique cisplatin-hydrazide and cisplatin-indocyanine green (ICG) coordination reactions. The nanoprodrug exhibited high drug loading efficiency and dual-responsive drug release behavior, showing potential in treating hepatocellular carcinoma.
It is still a huge challenge for concurrent highly efficient loading of chemotherapeutic agent and photosensitizer into single nanocarrier via stimuli-responsive linkages due to their different physicochemical properties and pharmacokinetics. Herein, based on the discovery of unique cisplatin-hydrazide and cisplatin-indocyanine green (ICG) coordination reactions, a multifunctional coordination nanoprodrug, cisplatin/ICG co-loaded hydrazided hyaluronan/bovine serum albumin (HBCI) nanoparticles, was developed by a desolvation-dual coordination process. The nanoprodrug exhibited ultrahigh drug loading efficiency and glutathione/NIR light dual-responsive drug release behavior. In vitro cellular studies demonstrated efficient internalization and apoptosis-inducing ability of the nanoprodrug in HepG2 cells. In vivo results confirmed the efficacious tumor accumulation and biosafety of HBCI nanoprodrug and synergistic effect of HBCI-based combined photodynamic chemotherapy on inhibiting tumor growth. Overall, this work not only provides a novel dual coordination approach for highly efficient loading of cisplatin and ICG but also verifies the therapeutic potential of HBCI nanoprodrug in combating hepatocellular carcinoma.
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