期刊
CARBOHYDRATE POLYMERS
卷 277, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118782
关键词
Chitosan; Capric acid; Oxidized dextran; Hemostatic sponge; Antibacterial activity
资金
- Natural Science Foundation of China (NSFC) [31400812]
The experiments showed that the synthesized porous C-OD2 sponge had appropriate porosity, swelling, absorption, water retention and mechanical properties, along with low toxicity, low hemolysis rate, suitable tissue adhesion and strong antibacterial efficacy. In animal injury models, C-OD2 demonstrated significantly lower hemostasis time and blood loss compared to commercial gelatin sponge.
This work aims to fabricate multifunctional hemostatic sponges (C-ODs). Porous C-ODs were first constructed by using capric acid-modified chitosan (CSCA) and oxidized dextrans (ODs) with different oxidation degrees. Batches of experiments showed that (i) CSCA (33.39% of grafting degree), ODs, and C-ODs (100-200 mu m in pore size) were synthesized, evidenced by FT-IR, H-1 NMR, elemental analysis, hydroxylamine hydrochloride titration, and SEM results; (ii) among C-ODs, C-OD2 had appropriate porosity (85.0%), swelling (20 times its dry weight), absorption, water retention, water vapor transmission, and mechanical properties; (iii) C-OD2 possessed low toxicity (relative cell viability > 86%), low hemolysis rate (0.65%), suitable tissue adhesion (4.74 kPa), and strong antibacterial efficacy (five strains); and (iv) C-OD2's dynamic blood clotting was within 30 s. In three animal injury models, C-OD2's hemostasis time and blood loss were fairly lower than commercial gelatin sponge. Totally, C-OD2 might serve as an ideal hemostatic dressing.
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