Size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres for endovascular embolization

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Targeted delivery of hemostats to complex bleeding wounds with magnetic guidance for instant hemostasis

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Summary: A magnetic field-guided hemostat has been developed for precise and instant hemorrhage control of complex bleeding wounds, demonstrating excellent biosafety through systematic assessments.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Biomedical

On-demand degradable embolic microspheres for immediate restoration of blood flow during image-guided embolization procedures

Hyunjun Choi et al.

Summary: The study introduces degradable and MRI-visible microspheres for embolotherapy, demonstrating their responsive on-demand degradation properties in vitro and in vivo. Successful embolization of hepatic arteries with these microspheres under DSA guidance was confirmed with images and contrast-enhanced MRI. The T2 MRI visibility of these microspheres allowed for monitoring their distribution during intra-arterial infusion.

BIOMATERIALS (2021)

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Article Chemistry, Applied

Modified porous carboxymethyl chitin microspheres by an organic solvent-free process for rapid hemostasis

Fan Leng et al.

Summary: A rapid and effective hemorrhage control method was developed using organic solvent-free carboxymethyl chitin microspheres loaded with calcium ions and dopamine polymerization. These modified microspheres demonstrated good biocompatibility and superior hemostatic performance compared to traditional controls, significantly reducing bleeding time in a femoral artery/vein cut model. This study suggests great potential for rapid hemostasis using these modified microspheres.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Modulation of Local Overactive Inflammation via Injectable Hydrogel Microspheres

Jiang Bian et al.

Summary: The injectable peptide-cell-hydrogel microsphere showed promising results in regulating ECM metabolism and inhibiting inflammatory responses, providing an effective approach for tissue regeneration under overactive inflammatory conditions.

NANO LETTERS (2021)

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Article Pharmacology & Pharmacy

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Jose Javier Lopez-Cano et al.

Summary: This study aimed to develop a thermo-responsive-injectable hydrogel based on PLGA-PEG-PLGA to deliver neuroprotective agents to the retina over time. Two PLGA-PEG PLGA copolymers with different ratios were synthesized and characterized, and HyG-1 was selected for further studies and loaded with anti-inflammatory drugs and antioxidants. In vitro drug release and cytotoxicity studies were performed, showing sustained release of drugs and good tolerance in retinal cells. The developed hydrogels represent a novel biodegradable tool for treating neurodegenerative processes in the retina.

PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation

Xiaohong Li et al.

Summary: This study successfully developed radiopaque and hemostatic microspheres by synthesizing barium sulfate nanoparticles with local procoagulant activity. The microspheres demonstrated significant hemostatic capacity and superior embolization effects in both in vitro and in vivo experiments.

BIOACTIVE MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Tunable Adhesion of Different Cell Types Modulated by Thermoresponsive Polymer Brush Thickness

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BIOMACROMOLECULES (2020)

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CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2020)

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Self-Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

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ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Biodegradable Polydioxanone Microspheres for Transcatheter Arterial Embolization: Proof of Principle

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JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Advances in Biomaterials and Technologies for Vascular Embolization

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ADVANCED MATERIALS (2019)

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Interaction of the synthetic antithrombotic peptide P10 with thrombin: a spectroscopy study

Fangyuan Chen et al.

RSC ADVANCES (2019)

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AASLD guidelines for the treatment of hepatocellular carcinoma

Julie K. Heimbach et al.

HEPATOLOGY (2018)

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Invivo characterization of a new type of biodegradable starch microsphere for transarterial embolization

Christof M. Sommer et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2018)

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Extra-small dual-lumen micro-balloon catheters can improve endovascular embolization: an experimental in vivo and in vitro study

Dominik F. Vollherbst et al.

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Review Radiology, Nuclear Medicine & Medical Imaging

Recent Update of Embolization of Postpartum Hemorrhage

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KOREAN JOURNAL OF RADIOLOGY (2018)

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Review Engineering, Biomedical

Advances in Degradable Embolic Microspheres: A State of the Art Review

Jensen Doucet et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2018)

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Review Engineering, Biomedical

Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab

Marcus Caine et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Review Engineering, Biomedical

Endovascular Embolization by Transcatheter Delivery of Particles: Past, Present, and Future

Rahul A. Sheth et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2017)

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Article Chemistry, Applied

Synthesis of carboxymethyl chitin in aqueous solution and its thermo- and pH-sensitive behaviors

Hui Liu et al.

CARBOHYDRATE POLYMERS (2016)

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Article Cardiac & Cardiovascular Systems

Temporary Arterial Embolization of Liver Parenchyma with Degradable Starch Microspheres (EmboCept(A (R))S) in a Swine Model

Claus C. Pieper et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2015)

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Poly(ethylene glycol) methacrylate hydrolyzable microspheres for transient vascular embolization

Stephanie Louguet et al.

ACTA BIOMATERIALIA (2014)

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In vitro and in vivo evaluation of chitosan microspheres with different deacetylation degree as potential embolic agent

Xuan Zhou et al.

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JOURNAL OF THE AMERICAN CERAMIC SOCIETY (2014)

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Article Medicine, General & Internal

Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial

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Onyx embolization of an extensive mandibular arteriovenous malformation via a dual lumen balloon catheter: a technical case report

Johanna Fifi et al.

Journal of NeuroInterventional Surgery (2012)

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Article Engineering, Chemical

Freeze-Drying of an Active Principle Ingredient Using Organic Co-Solvent Formulations: Influence of Freezing Conditions and Formulation on Solvent Crystals Morphology, Thermodynamics Data, and Sublimation Kinetics

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DRYING TECHNOLOGY (2011)

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Review Cardiac & Cardiovascular Systems

Analysis of Nontarget Embolization Mechanisms During Embolization and Chemoembolization Procedures

Ruben Lopez-Benitez et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2009)

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Editorial Material Gastroenterology & Hepatology

Role of transcatheter arterial embolization for massive bleeding from gastroduodenal ulcers

Romaric Loffroy et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

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Microspheres and Nonspherical Particles for Embolization

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Article Engineering, Biomedical

New acrylic microspheres for arterial embolization: Combining radiopacity for precise localization with immobilized thrombin to trigger local blood coagulation

Ketie Saralidze et al.

BIOMATERIALS (2007)

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Article Radiology, Nuclear Medicine & Medical Imaging

Chitin-based embolic materials in the renal artery of rabbits: Pathologic evaluation of an absorbable particulate agent

BK Kwak et al.

RADIOLOGY (2005)

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Size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres for endovascular embolization

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