期刊
CARBOHYDRATE POLYMERS
卷 286, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119274
关键词
Carboxymethyl chitin; Thrombin; Thermosensitivity; Hemostasis; Embolic microspheres
资金
- National Natural Science Foundation of China [21875168, 22175133]
- Fundamental Research Funds for the Central Universities of China [2042021kf1051]
- Key Program for International Science and Technology Coop-eration Projects of China [2021YFE0104100]
This study introduces a novel size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres, and demonstrates its effectiveness in hemostasis and endovascular embolization through in vitro and in vivo experiments.
As a minimally invasive method, endovascular embolization has been an effective strategy for controlling bleeding and tumor treatment. Herein, carboxymethyl chitin embolic microspheres were prepared with the aqueous two-phase carboxymethyl chitin/polyethylene glycol system without using any crosslinking agents and thrombin-functionalized embolic microsphere named as Thr@CMCHm-30 was made after covalent introduction of thrombin. The size of the microspheres can be adjusted from 5 to 500 mu m. The data of in vitro and in vivo tests indicated that these microspheres possessed good degradability and biocompatibility. Meanwhile, Thr@CMCHm30 can significantly promote blood clotting and enhance the strength of the blood clots. More importantly, Thr@CMCHm-30 displayed better embolization effect than that of the commercial available Gelfoam Alicon (R) and polyvinyl alcohol-based embolic microspheres CalliSpheres (R) in rat femoral vein and rabbit ear artery embolization models. Therefore the size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres Thr@CMCHm-30 possess great potential for effective hemostasis and endovascular embolization.
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