期刊
CARBOHYDRATE POLYMERS
卷 276, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118780
关键词
Photo-crosslinkable injectable hydrogels; Thiol-ene chemistry; Thiolated cellulose nanocrystal; Galactoglucomannan methacrylate; Bioactive glass nanoparticles
资金
- China Scholarship Council [201907960002]
- KAUTE Foundation [20190031]
- Academy of Finland [333158]
- Jane and Aatos Erkko Foundation
- Academy of Finland (AKA) [333158, 333158] Funding Source: Academy of Finland (AKA)
The study introduces an injectable nanocomposite hydrogel cured by light-induced thiol-ene addition, with features of faster crosslinking, more stable mechanics, and higher bioactivity, suitable for fabrication of digitally designed hydrogel constructs.
We propose an injectable nanocomposite hydrogel that is photo-curable via light-induced thiol-ene addition between methacrylate modified O-acetyl-galactoglucomannan (GGMMA) and thiolated cellulose nanocrystal (CNC-SH). Compared to free-radical chain polymerization, the orthogonal step-growth of thiol-ene addition allows a less heterogeneous hydrogel network and more rapid crosslinking kinetics. CNC-SH reinforced the GGMMA hydrogel as both a nanofiller and a crosslinker to GGMMA resulting in an interpenetrating network via thiol-ene addition. Importantly, the mechanical stiffness of the GGMMA/CNC-SH hydrogel is mainly determined by the stoichiometric ratio between the thiol groups on CNC-SH and the methacrylate groups in GGMMA. Meanwhile, the bioactive glass nanoparticle (BaGNP)-laden hydrogels of GGMMA/CNC-SH showed a sustained release of therapeutic ions in simulated body fluid in vitro, which extended the bioactive function of hydrogel matrix. Furthermore, the suitability of the GGMMA/CNC-SH formulation as biomaterial resin to fabricate digitally designed hydrogel constructs via digital light processing (DLP) lithography printing was evaluated.
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