期刊
CARBOHYDRATE POLYMERS
卷 269, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118346
关键词
Cellulose; Quantum dots; Ag; HR-TEM; Antimicrobial; Molecular docking study
资金
- HEC, Pakistan [21-1669/SRGP/RD/HEC/2017]
- King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia
In this study, Ag/cellulose nanocrystal-doped CeO2 quantum dots were synthesized and showed highly efficient catalytic performance in degrading methylene blue and ciprofloxacin in wastewater, particularly in acidic medium. Furthermore, the Ag/CNC-doped CeO2 exhibited significant antimicrobial activity against Gram-negative bacteria in in vitro experiments.
In the present study, the novel Ag/cellulose nanocrystal (CNC)-doped CeO2 quantum dots (QDs) with highly efficient catalytic performance were synthesized using one pot co-precipitation technique, which were then applied in the degradation of methylene blue and ciprofloxacin (MBCF) in wastewater. Catalytic activity against MBCF dye was significantly reduced (99.3%) for (4%) Ag dopant concentration in acidic medium. For Ag/CNCdoped CeO2 vast inhibition domain of G-ve was significantly confirmed as (5.25-11.70 mm) and (7.15-13.60 mm), while medium- to high-concentration of CNC levels were calculated for G + ve (0.95 nm, 1.65 mm), respectively. Overall, (4%) Ag/CNC-doped CeO2 revealed significant antimicrobial activity against G-ve relative to G + ve at both concentrations, respectively. Furthermore, in silico molecular docking studies were performed against selected enzyme targets dihydrofolate reductase (DHFR), dihydropteroate synthase (DHPS), and DNA gyrase belonging to folate and nucleic acid biosynthetic pathway, respectively to rationalize possible mechanism behind bactericidal potential of CNC-CeO2 and Ag/CNC-CeO2.
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