期刊
CANCER RESEARCH
卷 82, 期 1, 页码 75-89出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-21-1473
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- Ministry of Science and Technology in Taiwan [MOST 109-2320-B-075-001, MOST 110-2320-B-075-006-MY3]
- Taipei Veterans General Hospital [V108D46-004-MY2-2, V109E-007-4, V109E-007-5, V110C-187]
- IBMS CRC Research Program of the Institute of Biomedical Sciences, Academia Sinica [IBMS-CRC109-P04]
- Veterans Affairs Council [110VACS-003, 110VACS-007]
- SPROUT Project-Center For Intelligent Drug Systems and Smart Bio-devices (IDS2B) of National Chiao Tung University
- Cancer Progression Research Center, National Yang-Ming Chiao-Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan
Lung cancers, particularly non-small cell lung cancers, have a poor prognosis. A circular noncoding RNA called C190 has been identified as a negative prognostic biomarker for lung cancer, and this study explores its mechanistic function and potential as a therapeutic target for NSCLC.
Lung cancers are the leading cause of cancer-related mortality worldwide, and the majority of lung cancers are non-small cell lung associated with a poor prognosis in NSCLC. We previously identified a circular noncoding RNA, hsa_circ_0000190 (C190), as a negative prognostic biomarker of lung cancer. Here, we attempted to dissect the mechanistic function of C190 and test the potential of C190 as a therapeutic target in NSCLC. C190 was upregulated in both NSCLC clinical samples and cell lines. Activation of the EGFR pathway increased C190 expression through a MAPK/ERK-dependent mechanism. Transient and stable overexpression of C190 induced ERK1/2 phosphorylation, proliferation, and migration in vitro and xenograft tumor growth in vivo. RNA sequencing and Expression2Kinases (X2K) analysis indicated that kinases associated with cell-cycle and global translation are involved in C190-activated networks,
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