期刊
CANCER RESEARCH
卷 81, 期 23, 页码 5800-5802出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-21-3302
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类别
资金
- China Scholarship Council Scholarship
- American Cancer Society Professorship
- Ludwig Cancer Research, Brewster Foundation
- Breast Cancer Research Foundation
- US Department of Defense
- Susan G. Komen Foundation
- US National Institutes of Health
Loss of E-cadherin is not only linked to cancer metastasis, but also influences cell signaling events and cellular plasticity. This study highlighted the importance of E-cadherin as a global regulator in driving EMT and the metastatic phenotype, inspiring further research in the field.
Loss of E-cadherin expression has been well known as a hallmark of epithelial-mesenchymal transition (EMT), which is linked to increased risk of cancer metastasis. However, it was less clear whether E-cadherin and its downstream signaling pathways are functionally involved in driving EMT and the prometastatic phenotype. A study by Onder and colleagues in 2008 discovered that E-cadherin loss not only helps tumor cells detach from each other by breaking down cell-cell junctions but also elicits intracellular signaling events to confer a mesenchymal cell state and metastatic phenotype. This study established E-cadherin as an important global regulator, rather than just a marker, of EMT. The discovery inspired further investigation in the following decade that significantly deepened our understanding of E-cadherin and its diverse functions and more broadly of cellular plasticity in different stages and contexts of cancer metastasis.
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