期刊
CANCER RESEARCH
卷 82, 期 3, 页码 365-376出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-21-0253
关键词
-
类别
资金
- imCORE Network, project USC-3 on behalf of Genentech Inc.
- NIH [R01CA190980, R01CA1239235, R01CA190980S1, T32CA108462]
- National Cancer Institute of the National Institutes of Health [P30CA082103]
In breast cancer, the distribution of infiltrating immune cells is associated with clinical outcome. Tumors with abundant tumor-infiltrating lymphocytes are more likely to respond to immunotherapy, while those without or with excluded CD8 T cells are less likely to respond. However, the understanding of this biology is limited due to a lack of preclinical breast cancer models that recapitulate the distribution of tumor-infiltrating lymphocytes.
In breast cancer, the type and distribution of infiltrating immune cells are associated with clinical outcome. Moreover, cancers with abundant tumor-infiltrating lymphocytes (TIL) are more likely to respond to immunotherapy, whereas those in which CD8 thorn T cells are completely absent (deserts) or excluded are less likely to respond. Detailed understanding of this biology is limited by a lack of preclinical breast cancer models that recapitulate TIL distributions and their associated biology. Here we established mammary tumor-derived transplants (mTDT) from 12 Trp53-null mammary tumors in syngeneic BALB/cJ mice and examined the stability of their growth rate, TIL distribution, and transcriptomic profiles. All mTDTs were estrogen receptor negative. Half of the parental tumors were classified as infiltrated, and the rest were divided between excluded and desert phenotypes. After two orthotopic passages, most (70%) mTDT from infiltrated parents recapitulated this pattern, whereas the desert or excluded parental patterns were
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据