4.7 Article

Androgen receptor (AR) heterogeneity in prostate cancer and therapy resistance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Urology & Nephrology

Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy

Scott Wilkinson et al.

Summary: The study aimed to identify genomic and histologic features associated with treatment resistance at baseline, finding that some prostate cancer tumors exhibit greater histologic and genomic diversity at the time of diagnosis, making them more resistant to therapy.

EUROPEAN UROLOGY (2021)

Article Biotechnology & Applied Microbiology

Functional mapping of androgen receptor enhancer activity

Chia-Chi Flora Huang et al.

Summary: Using a functional map of AR enhancer activity, it was demonstrated that AR-regulated enhancers act as a regulatory hub that increases interactions with other AR binding sites and gene promoters. The study found that only 7% of AR binding sites display androgen-dependent enhancer activity, while the vast majority were either inactive or constitutively active enhancers. Somatic mutations of critical AR-regulated enhancers often impact enhancer activity.

GENOME BIOLOGY (2021)

Article Oncology

Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer

Alexandra N. Corella et al.

CLINICAL CANCER RESEARCH (2020)

Article Multidisciplinary Sciences

A case report of multiple primary prostate tumors with differential drug sensitivity

Scott Wilkinson et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Mitochondrial localization, import, and mitochondrial function of the androgen receptor

Prachi Bajpai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Cell Biology

The androgen receptor regulates a druggable translational regulon in advanced prostate cancer

Yuzhen Liu et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Medicine, Research & Experimental

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

Mark P. Labrecque et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Biochemistry & Molecular Biology

Membrane-associated androgen receptor (AR) potentiates its transcriptional activities by activating heat shock protein 27 (HSP27)

Jianzhuo Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

Qiuhui Li et al.

NATURE COMMUNICATIONS (2018)

Review Oncology

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Philip A. Watson et al.

NATURE REVIEWS CANCER (2015)

Article Pathology

Proposed Morphologic Classification of Prostate Cancer With Neuroendocrine Differentiation

Jonathan I. Epstein et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2014)

Article Oncology

Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

Hsueh-Li Tan et al.

CLINICAL CANCER RESEARCH (2014)

Article Biochemistry & Molecular Biology

Cooperation between Polycomb and androgen receptor during oncogenic transformation

Jonathan C. Zhao et al.

GENOME RESEARCH (2012)

Article Genetics & Heredity

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Christopher E. Barbieri et al.

NATURE GENETICS (2012)

Review Multidisciplinary Sciences

Cells of origin in cancer

Jane E. Visvader

NATURE (2011)

Article Multidisciplinary Sciences

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

Philip A. Watson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Endocrinology & Metabolism

The Contribution of Different Androgen Receptor Domains to Receptor Dimerization and Signaling

Margaret M. Centenera et al.

MOLECULAR ENDOCRINOLOGY (2008)

Article Multidisciplinary Sciences

Targeting the stromal androgen receptor in primary prostate tumors at earlier stages

Yuanjie Niu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Androgen receptor is a tumor suppressor and proliferator in prostate cancer

Yuanjie Niu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor

Chun-Te Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Oncology

Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer

MA Titus et al.

CLINICAL CANCER RESEARCH (2005)

Article Multidisciplinary Sciences

Mutation of the androgen receptor causes oncogenic transformation of the prostate

GZ Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Molecular determinants of resistance to antiandrogen therapy

CD Chen et al.

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

Formation of the androgen receptor transcription complex

YF Shang et al.

MOLECULAR CELL (2002)

Article Multidisciplinary Sciences

Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium

M Stanbrough et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)