期刊
CANCER LETTERS
卷 526, 期 -, 页码 225-235出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.11.027
关键词
Colorectal cancer; Gut microbiota; Short-chain fatty acids; Tumor immunity
类别
资金
- National Natural Science Foundation of China [82070545, 81970477]
- Key Project of Science and Technology Pillar Program of Tianjin [20YFZCSY00020]
- Tianjin Research Innovation Project for Postgraduate Students [2020YJSS175]
Colorectal cancer is the third most common cancer worldwide, and its development is closely related to changes in the gut microbiota and metabolites. Short-chain fatty acids play a crucial role in promoting intestinal health, inhibiting tumor development, and enhancing responses to chemotherapy and immunotherapy.
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. It involves the complex interactions between genetic factors, environmental exposure, and gut microbiota. Specific changes in the gut microbiome and metabolome have been described in CRC, supporting the critical role of gut microbiota dysbiosis and microbiota-related metabolites in the tumorigenesis process. Shortchain fatty acids (SCFAs), the principal metabolites generated from the gut microbial fermentation of insoluble dietary fiber, can directly activate G-protein-coupled receptors (GPCRs), inhibit histone deacetylases (HDACs), and serve as energy substrates to connect dietary patterns and gut microbiota, thereby improving the intestinal health. A significantly lower abundance of SCFAs and SCFA-producing bacteria has been demonstrated in CRC, and the supplementation of SCFA-producing probiotics can inhibit intestinal tumor development. SCFAs-guided modulation in both mouse and human CRC models augmented their responses to chemotherapy and immunotherapy. This review briefly summarizes the complex crosstalk between SCFAs and CRC, which might inspire new approaches for the diagnosis, treatment and prevention of CRC on the basis of gut microbiota-derived metabolites SCFAs.
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