4.7 Article

Cigarette smoking induces aberrant N6-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-ΚB pathway

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Summary: N6-methyladenosine (m(6)A) modification of ZBTB4 via EZH2, mediated by METTL3, is involved in cigarette smoke-induced epithelial-mesenchymal transition (EMT) and lung cancer. The higher expression of METTL3 in lung tissues of smokers is inversely correlated with ZBTB4 levels. These findings suggest that m(6)A modifications could be a potential therapeutic target for lung damage induced by cigarette smoke.

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