期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 31, 期 4, 页码 870-875出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-21-0782
关键词
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资金
- NIH [R01 CA124709, R01 CA180692, R35 CA220500]
- Associazione Italiana per la Ricerca sul Cancro [20757]
- Giulio D'Angio Endowed Chair
- Children's Hospital of Philadelphia Endowed Chair in Genetics Research
Neuroblastoma is less common in African American children, but they more frequently develop the high-risk form of the disease. The study suggests that several common variants contribute to neuroblastoma risk in an ancestry-specific fashion.
Background: Neuroblastoma is rarer in African American (AA) children compared with American children of European descent. AA children affected with neuroblastoma, however, more frequently develop the high-risk form of the disease. Methods: We have genotyped an AA cohort of 629 neuroblastoma cases (254 high-risk) and 2,990 controls to investigate genetic susceptibility to neuroblastoma in AAs. Results: We confirmed the known neuroblastoma susceptibility gene BARD1 at genome-wide significance in the subset of high-risk cases. We also estimated local admixture across the autosomal genome in the AA cases and controls and detected a signal at 4q31.22 where cases show an increase in European ancestry. A region at 17p13.1 showed increased African ancestry in the subgroup of high-risk cases with respect to intermediate- and low-risk cases. Using results from our published European American (EA) genome-wide association study (GWAS), we found that a polygenic score that included all independent SNPs showed a highly significant association (P value = 1.8 x 10(-73)) and explained 19% of disease risk variance in an independent EA cohort. In contrast, the best fit polygenic score (P value = 3.2 x 10(-11)) in AAs included only 22 independent SNPs with association P value < 2.75 x 10(-6) in the EA GWAS, and explained 2% of neuroblastoma risk variance. The significance of the polygenic score dropped rapidly with inclusion of additional SNPs. Conclusions: These findings suggest that several common variants contribute to risk of neuroblastoma in an ancestry-specific fashion. Impact: This work supports the need for GWAS to be performed in populations of all races and ethnicities.
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