4.8 Article

Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)

Alexander M. Menzies et al.

Summary: A pooled analysis of neoadjuvant immunotherapy trials in melanoma revealed that the degree of pathological response is correlated with patient survival, serving as a potential surrogate marker for long-term outcomes. Patients with pathological complete response (pCR) after immunotherapy showed significantly improved recurrence-free survival (RFS) and overall survival (OS) compared to those without pCR. Pathological response, particularly pCR, could be an early surrogate endpoint for clinical trials and a new benchmark for development and approval in melanoma.

NATURE MEDICINE (2021)

Review Peripheral Vascular Disease

High endothelial venules (HEVs) in immunity, inflammation and cancer

Lucas Blanchard et al.

Summary: High endothelial venules (HEVs) are essential for lymphocyte circulation and immune surveillance in lymph nodes and secondary lymphoid organs. These specialized blood vessels expand during inflammation and play important roles in chronic inflammatory diseases. MECA-79(+) tumor-associated HEVs also play crucial roles in promoting lymphocyte entry into tumors in cancer immunotherapy.

ANGIOGENESIS (2021)

Review Oncology

The Next Decade of Immune Checkpoint Therapy

Padmanee Sharma et al.

Summary: Immune checkpoint therapy can provide durable antitumor responses for subsets of cancer patients, but challenges remain in understanding resistance mechanisms, optimizing patient selection, managing immune-related adverse events, and identifying rational therapeutic combinations. A focused approach encompassing clinical and basic research with integration of reverse translational studies is needed to address these challenges and guide the development of novel combination strategies.

CANCER DISCOVERY (2021)

Article Multidisciplinary Sciences

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

Christiane S. Eberhardt et al.

Summary: The study identified different transcriptional subsets of HPV-specific CD8 T cells in HPV-positive head and neck cancer, highlighting the potential response to PD-1 blockade. Furthermore, the inclusion of E2 and E5 proteins in HPV therapeutic vaccines should be considered to elicit a broader tumor-reactive CD8 T cell response.

NATURE (2021)

Article Multidisciplinary Sciences

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

Giacomo Oliveira et al.

Summary: The authors demonstrate through single-cell profiling and T cell receptor specificity screening that tumour antigen recognition influences the phenotypes of CD8(+) T cells and antitumour immune responses. Non-tumour-reactive T cells show a non-exhausted memory phenotype, while melanoma-reactive lymphocytes exhibit an exhausted state, providing insights into the properties of the anti-melanoma TCR repertoire.

NATURE (2021)

Article Multidisciplinary Sciences

Peripheral T cell expansion predicts tumour infiltration and clinical response

Thomas D. Wu et al.

NATURE (2020)

Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Clonal replacement of tumor-specific T cells following PD-1 blockade

Kathryn E. Yost et al.

NATURE MEDICINE (2019)

Article Medicine, General & Internal

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies

Spencer C. Wei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Caroline S. Jansen et al.

NATURE (2019)

Review Multidisciplinary Sciences

Cancer immunotherapy using checkpoint blockade

Antoni Ribas et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Moshe Sade-Feldman et al.

Article Biochemistry & Molecular Biology

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

Rodabe N. Amaria et al.

NATURE MEDICINE (2018)

Article Biochemical Research Methods

Single-cell mRNA quantification and differential analysis with Census

Xiaojie Qiu et al.

NATURE METHODS (2017)

Article Cell Biology

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation

Elizabeth Allen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Oncology

Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction

Emily J. Colbeck et al.

CANCER IMMUNOLOGY RESEARCH (2017)

Article Biochemistry & Molecular Biology

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

Spencer C. Wei et al.

Article Biochemistry & Molecular Biology

Systemic Immunity Is Required for Effective Cancer Immunotherapy

Matthew H. Spitzer et al.

Article Multidisciplinary Sciences

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng et al.

NATURE (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Multidisciplinary Sciences

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Matthew M. Gubin et al.

NATURE (2014)

Article Multidisciplinary Sciences

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Paul C. Tumeh et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

Gregory T. Motz et al.

NATURE MEDICINE (2014)

Article Cell Biology

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response

Pia Kvistborg et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

Article Cell Biology

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

Stefani Spranger et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Biotechnology & Applied Microbiology

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim et al.

GENOME BIOLOGY (2013)

Article Immunology

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

Timothy O'Sullivan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Review Immunology

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

Jean-Philippe Girard et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Biochemical Research Methods

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li et al.

BMC BIOINFORMATICS (2011)

Article Immunology

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

Mark S. Diamond et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Multidisciplinary Sciences

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

Christine Moussion et al.

NATURE (2011)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

Article Biochemistry & Molecular Biology

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

Ronald J. Buckanovich et al.

NATURE MEDICINE (2008)

Article Oncology

The application of a murine bone bioreactor as a model of tumor: bone interaction

Jennifer Halpern et al.

CLINICAL & EXPERIMENTAL METASTASIS (2006)