期刊
CANCER CELL
卷 40, 期 2, 页码 120-122出版社
CELL PRESS
DOI: 10.1016/j.ccell.2022.01.009
关键词
-
资金
- NIH, United States [CA206105]
- DOD [W81XWH-19-1-0605]
- DOD, United States [W81XWH-19-1-0603]
The study identifies IL-33, a pro-inflammatory cytokine, as a chemotactic factor released in response to intratumoral mycobiome that attracts type 2 immune cells. Depletion of fungi or deletion of IL-33 significantly decreases pancreatic ductal adenocarcinoma (PDAC) tumor progression and improves survival.
In this issue of Cancer Cell, Aftab et al. identify a pro-inflammatory cytokine, IL-33, that is released as a che-moattractant for type 2 immune cells in response to the intratumoral mycobiome. Depletion of fungi or deletion of IL-33 in cancer cells significantly decreases pancreatic ductal adenocarcinoma (PDAC) tumor progression and increases survival.
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