Tumor-infiltrated T cells with stem-cell-like properties play a crucial role in determining the response to immunotherapy. The latest research suggests that their entry into tumor tissue relies on specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels. Furthermore, immunotherapy has been found to enhance the recruitment capacity of these endothelial cells.
Tumor-infiltrated T cells with stem-cell-like properties are important for determining the immunotherapy response. In this issue of Cancer Cell, Asrir and colleagues show that their entry requires specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels and that immunotherapy enhances the recruitment capacity of these endothelial cells.
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