期刊
CANADIAN JOURNAL OF CARDIOLOGY
卷 38, 期 5, 页码 699-702出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cjca.2021.12.021
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There are significant gaps in clinical evidence in the management and treatment of peripheral artery disease (PAD) due to ongoing challenges in implementing and designing clinical trials within this field, including fragmented care, coexistence of other cardiovascular diseases, difficulties in recruiting patients, lack of diversity, limited research focus, and insufficient validation evidence.
There remain significant gaps in clinical evidence in the management and treatment of peripheral artery disease (PAD). Many of these gaps exist as a result of ongoing challenges in the implementation and design of clinical trials within the PAD clinical space. These challenges include the often-fragmented state of PAD clinical care, the frequent coexistence of other cardiovascular disease states, difficulties with recruiting PAD patients into clinical trials, a lack of diversity within PAD clinical trials, the limited focus of PAD clinical trials, and the sparse validation evidence of secondary end points and patient-reported outcome measures in PAD trials.
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