C(sp3) -H Bond Functionalization Mediated by Hydride a Shift/Cyclization System

An efficient catalytic internal redox reaction (hydride shift mediated C(sp(3))-H bond functionalization) has been developed, which has the following salient features: (1) C(sp(3))-H bond functionalization, (2) Lewis and/or Bronsted acid catalyzed reaction (transition metals employed in conventional CH bond functionalization are not required), and (3) construction of complex polycycles that are otherwise difficult to synthesize by conventional methods. Our recent efforts on the development of novel types of C(sp(3))-H bond functionalization mediated by the hydride shift/cyclization system are described.

Automated summary

An efficient catalytic internal redox reaction, which does not require transition metals commonly used in conventional CH bond functionalization, has been developed to construct complex polycycles that are challenging to synthesize by traditional methods.