4.4 Editorial Material

Special Collection: Celebrating JD Murray's Contributions to Mathematical Biology

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Review Biology

Modelling Cell Invasion: A Review of What JD Murray and the Embryo Can Teach Us

Paul M. Kulesa et al.

Summary: Cell invasion and cell plasticity play crucial roles in human development and cancer metastasis, involving complex cell signaling and interactive behaviors. Researchers have recognized the importance of mathematics in biology and developed a unique mathematical strategy to address these complex biological questions.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Controlling the Spatial Spread of a Xylella Epidemic

Sebastian Anita et al.

Summary: The research presents a simple model to describe the spread of Olive Quick Decline Syndrome and identifies possible strategies to control the epidemic. Numerical simulations support the model, showing that removing weed biomass and adopting more resistant olive tree cultivars can be effective control measures.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

The Role of Cytoplasmic MEX-5/6 Polarity in Asymmetric Cell Division

Sungrim Seirin-Lee

Summary: This study explored the interaction between cytoplasmic MEX-5/6 polarity and membrane PAR polarity by developing a mathematical model that integrates their dynamics and reflects cell geometry. The results showed that the downstream cytoplasmic protein MEX-5/6 plays a crucial role in generating a strong upstream PAR polarity, highlighting the importance of understanding their interplay, including the influence of cell geometry, in studying polarity formation during asymmetric cell division.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Calcium Dynamics and Water Transport in Salivary Acinar Cells

James Sneyd et al.

Summary: Saliva is secreted from the acinar cells of the salivary glands in a mechanism similar to other water-transporting epithelial cells. Over the past 20 years, a quantitative model of saliva secretion has been continuously developed and modified, with a focus on the control by intracellular calcium dynamics. Recent advancements in understanding the underlying mechanisms have led to important modifications to the traditional view of saliva secretion.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Generalized Stoichiometry and Biogeochemistry for Astrobiological Applications

Christopher P. Kempes et al.

Summary: The article discusses the application of research on elemental ratios of life forms to astrobiology, including predicting variations in elemental ratios in different environments and exploring the possibility of extending physiological models for future astrobiological applications.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Bespoke Turing Systems

Thomas E. Woolley et al.

Summary: The translation discusses the parameters and processes involved in pattern formation in reaction-diffusion systems.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

The Signature of Endemic Populations in the Spread of Mountain Pine Beetle Outbreaks

Dean Koch et al.

Summary: The mountain pine beetle is a destructive forest pest in North America, with an increasing frequency and severity of outbreaks prompting interest in its population ecology. Modern approaches involve analyzing large-scale datasets and developing new modeling tools to address challenges associated with large sample sizes and spatial effects. Research has focused on using separable kernels to address computational challenges in dispersal and spatial autocorrelation of the MPB.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

The Effect of Covert and Overt Infections on Disease Dynamics in Honey-Bee Colonies

Nicholas F. Britton et al.

Summary: The study of viral diseases in honey bees requires consideration of infection statuses, including covert infections, acutely overt infections, and chronically overt infections. It is also important to focus on the infection statuses of vectors in order to fully understand the dynamics of disease transmission.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Modeling the Effect of HIV/AIDS Stigma on HIV Infection Dynamics in Kenya

Ben Levy et al.

Summary: Stigma towards people living with HIV/AIDS has hindered global response to the disease, with internalized and enacted stigma being key components. Particularly high in sub-Saharan Africa, stigma has contributed to a surge in cases in countries like Kenya. Efforts to eliminate stigma have improved perceptions over time, but HIV/AIDS remains a significant problem, prompting analysis of different interventions and goals for the future.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Atto-Foxes and Other Minutiae

A. C. Fowler

Summary: This paper addresses the issue of extinction in continuous population dynamics models with small numbers of individuals. It discusses extinction in the context of a stochastic logistic model, provides examples of 'small number dynamics,' such as the 'atto-fox' and 'frogspawn' problems, and proposes modeling solutions to address these issues.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Modelling Preferential Phagocytosis in Atherosclerosis: Delineating Timescales in Plaque Development

Gigi Lui et al.

Summary: The development of atherosclerotic plaques and their impact on heart attacks and strokes are complex processes that involve lipid dynamics and macrophage behavior. The proposed ODE model explores the dynamics of lipids and macrophages in plaque formation.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Mechanical Models of Pattern and Form in Biological Tissues: The Role of Stress-Strain Constitutive Equations

Chiara Villa et al.

Summary: Mechanical and mechanochemical models of pattern formation in biological tissues, considering different stress-strain constitutive equations for the ECM, reveal that fluid-like constitutive models such as Maxwell and Jeffrey models have higher pattern formation potential compared to solid-like models like Kelvin-Voigt and standard linear solid models. This finding suggests the importance of acquiring detailed quantitative information on the mechanical properties of ECM components in various biological tissues to improve the accuracy of mechanical models in representing tissue rheology.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

A Comparison of the Reduced Losses and Increased Production Models for Mussel Bed Dynamics

Jonathan A. Sherratt et al.

Summary: The study proposes a generalized model for pattern formation in ecosystems, integrating two types of within-patch feedback mechanisms: growth amplification and reduction of losses. Results show significant differences between the patterns generated by the two mechanisms, particularly in terms of biomass distribution and resilience to disturbances.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

A Random Walk Approach to Transport in Tissues and Complex Media: From Microscale Descriptions to Macroscale Models

Jay A. Stotsky et al.

Summary: The biological processes that drive the development and survival of organisms are heavily influenced by transport properties of biologically active species across different temporal and spatial scales. This study employs multistate continuous-time random walks and generalized master equations to model complex transport processes involving spatial jumps and internal state changes, with the goal of understanding macroscopic transport coefficients in terms of microscale properties. The results of this work have broad applications beyond biological tissue transport, offering insights into a diverse range of problems.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Article Biology

Characterizing Chemotherapy-Induced Neutropenia and Monocytopenia Through Mathematical Modelling

Tyler Cassidy et al.

BULLETIN OF MATHEMATICAL BIOLOGY (2020)

Article Biology

A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma

Lee Curtin et al.

BULLETIN OF MATHEMATICAL BIOLOGY (2020)

Review Clinical Neurology

Virtual and real brain tumors: using mathematical modeling' to quantify glioma growth and invasion

KR Swanson et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2003)

Article Biology

A model of HIV-1 pathogenesis that includes an intracellular delay

PW Nelson et al.

MATHEMATICAL BIOSCIENCES (2000)