Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes

Article Pharmacology & Pharmacy

Nifedipine Does Not Alter the Pharmacokinetics of Venlafaxine Enantiomers in Healthy Subjects Phenotyped for CYP2D6, CYP2C19, and CYP3A

Eduardo Tozatto et al.

Summary: The study aimed to investigate whether nifedipine alters the kinetic disposition of VEN enantiomers and their metabolites in healthy subjects. The results showed that a single oral dose of 40 mg nifedipine did not alter the pharmacokinetics of VEN enantiomers in healthy subjects.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

CYP2D6*10 polymorphism and the enantioselective O-desmethylation of S-(+)- and R-(-)-venlafaxine in Japanese psychiatric patients

Taro Sasaki et al.

Summary: The study found that CYP2D6*10 genotypes have significant effects on the plasma concentrations of venlafaxine enantiomers in Japanese depressed patients. The mutated alleles of CYP2D6*10 may result in higher plasma concentrations of S-(+)-VEN and R-(-)-VEN. Further research is needed to understand how these genetic variations impact clinical practices.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2021)

添加到收藏夹

Review Chemistry, Applied

Targeted Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells: A new Direction for Therapy in Regenerative Medicine

Gleb N. Zyuz'kov

Summary: The translation discusses the scientific and theoretical basis for targeted therapy in regenerative medicine, focusing on the pharmacological regulation of intracellular signal transduction in regeneration-competent cells. It emphasizes the importance of using intracellular signaling molecules as targets for drugs with regenerative activity, and highlights the role of different progenitor cells and specific signaling molecules in the regeneration process.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Specific Features of Intracellular Signal Transduction in the Regulation of Functions of Neural Stem Cells and Committed Neuronal Progenitors

G. N. Zyuz'kov et al.

Summary: The study identified that blocking signaling pathways have different impacts on progenitor cells of different classes, suggesting potential for developing new drugs to promote neuroregeneration. Inhibiting STAT3 and activating JNK did not negatively affect the function of neural stem cells and neuronal progenitors.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Chemistry, Applied

Prospects for the Use of NF-κb Inhibitors to Stimulate the Functions of Regeneration-Competent Cells of Nerve Tissue and Neuroregeneration in Ethanol-Induced Neurodegeneration

Gleb Nikolaevich Zyuz'kov et al.

Summary: The research found that NF-kappa B hinders the specialization process of neural stem cells, while having minimal harmful effects on the proliferation of neural stem cells and neuronal-committed progenitors. Additionally, NF-kappa B is involved in the secretory function of astrocytes and oligodendrocytes.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy