期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 172, 期 3, 页码 359-363出版社
SPRINGER
DOI: 10.1007/s10517-022-05392-8
关键词
boron neutron capture therapy; accelerator based epithermal neutron source; boronophenylalanine; sodium borocaptate; human colorectal adenocarcinoma
资金
- Russian Science Foundation [19-72-30005]
- Ministry of Education and Science of Russian Federation [RFMEFI62117X0015]
This study evaluated the effectiveness of BNCT in treating malignant neoplasms of the rectum and colon. The results showed that BNCT treatment with BPA and BSH injections significantly decreased tumor volumes.
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronophenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).
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