4.6 Article

Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy

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BRITISH JOURNAL OF OPHTHALMOLOGY
卷 107, 期 7, 页码 993-999

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BMJ PUBLISHING GROUP
DOI: 10.1136/bjophthalmol-2021-319739

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Optical coherence tomography angiography (OCTA) parameters from both the retinal and choroidal microvasculature can be used to detect the presence and severity of diabetic retinopathy (DR). Choriocapillaris parameters show better discrimination between non-diabetic and diabetic without DR groups. Evaluating both retinal and choroidal microvasculature significantly improves the detection of diabetic retinopathy.
Purpose To use optical coherence tomography angiography (OCTA) parameters from both the retinal and choroidal microvasculature to detect the presence and severity of diabetic retinopathy (DR). Method This is a cross-sectional case-control study. OCTA parameters from retinal vasculature, fovea avascular zone (FAZ) and choriocapillaris were evaluated from 3x3 mm(2) fovea-centred scans. Areas under the receiver operating characteristic (ROC) curve were used to compare the discriminative power on the presence of diabetes mellitus (DM), the presence of DR and need for referral: group 1 (no DM vs DM no DR), group 2 (no DR vs any DR) and group 3 (non-proliferative DR (NPDR) vs proliferative DR (PDR)). Results 35 eyes from 27 participants with no DM and 132 eyes from 75 with DM were included. DR severity was classified into three groups: no DR group (62 eyes), NPDR (51 eyes), PDR (19 eyes). All retinal vascular parameters, FAZ parameters and choriocapillaris parameters were strongly altered with DR stages (p<0.01), except for the deep plexus FAZ area (p=0.619). Choriocapillaris parameters allowed to better discriminate between no DM versus DM no DR group compared with retinal parameters (areas under the ROC curve=0.954 vs 0.821, p=0.006). A classification model including retinal and choroidal microvasculature significantly improved the discrimination between DR and no DR compared with each parameter separately (p=0.029). Conclusions Evaluating OCTA parameters from both the retinal and choroidal microvasculature in 3x3 mm scans improves the discrimination of DM and early DR.

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