期刊
BRITISH JOURNAL OF NUTRITION
卷 128, 期 6, 页码 1100-1107出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114521004335
关键词
Hearing loss; Lead; Cadmium; Selenium; Exposure
资金
- National Natural Science Foundation of China [81771002, 82071057, 82000988]
- Research fund of Wuhan Union hospital [02.03.2019-114]
This study found a significant association between blood levels of cadmium and selenium with hearing loss, especially in adults aged 35-52. Among different genders, the hearing loss in men showed a dose-dependent relationship with blood selenium levels, while in women, only cadmium levels were associated with speech and high-frequency hearing loss.
To determine the association between hearing loss and environmental Pb, Cd and Se exposure, a total of 1503 American adults from National Health and Nutrition Examination Survey (NHANES) (2011-2012) were assessed. The average of four audiometric frequencies (0 center dot 5, 1, 2 and 4 kHz) was used to identify speech-frequency hearing loss (SFHL), while the average of 3 audiometric frequencies (3, 4 and 6 kHz) was used to identify high-frequency hearing loss (HFHL). HFHL adjusted OR determined by comparing the highest and lowest blood Pb and Cd quartiles were 1 center dot 98 (95 % CI: 1 center dot 27, 3 center dot 10) and 1 center dot 81 (95 % CI: 1 center dot 13, 2 center dot 90), respectively. SFHL was significantly associated with blood Cd with the OR = 2 center dot 42 for the highest quartile. When further stratified by age, this association appeared to be limited to adults aged 35-52 years. After stratified by gender, except for Pb and Cd, we observed that blood Se showed a dose-dependent association with SFHL in men. In women, only Cd showed a dose-dependent association with speech and high-frequency hearing loss. Hearing loss was positively associated with blood levels of Pb and Cd. Additionally, our study provided novel evidence suggesting that excessive Se supplement would increase SFHL risk in men.
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