期刊
BRITISH JOURNAL OF NUTRITION
卷 128, 期 7, 页码 1206-1219出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114522000034
关键词
Acebuche; Aorta; Arterial hypertension; Endothelial dysfunction; NG-nitro-l-arginine methyl ester; Wild olive oil
资金
- Consejeria de Economia, Conocimiento, Empresas y Universidad, Junta de Andalucia [2020/275, CTS-584]
- Ministerio de Ciencia, Innovacion y Universidades [FPU17/03465]
- Ministerio de Ciencia e Innovacion, Ayudas para la Promocion de Empleo Joven e Implantacion de la Garantia Juvenil en I thorn D thorn i 2017-2020 [PEJ2018-004474-A]
This study demonstrates the beneficial effects of wild olive oil, ACE, in reducing blood pressure and counteracting hypertension-induced vascular alterations. Regular inclusion of ACE oil in the diet can alleviate vascular remodeling and endothelial dysfunction typically found in arterial hypertension.
Despite numerous reports on the beneficial effects of olive oil in the cardiovascular context, very little is known about the olive tree's wild counterpart (Olea europaea, L. var. sylvestris), commonly known as acebuche (ACE) in Spain. The aim of this study was to analyse the possible beneficial effects of an extra virgin ACE oil on vascular function in a rodent model of arterial hypertension (AH) induced by N-G-nitro-l-arginine methyl ester (L-NAME). Four experimental groups of male Wistar rats were studied: (1) normotensive rats (Control group); (2) normotensive rats fed a commercial diet supplemented with 15 % (w/w) ACE oil (Acebuche group); (3) rats made hypertensive following administration of L-NAME (L-NAME group); and (4) rats treated with L-NAME and simultaneously supplemented with 15 % ACE oil (LN + ACE group). All treatments were maintained for 12 weeks. Besides a significant blood pressure (BP)-lowering effect, the ACE oil-enriched diet counteracted the alterations found in aortas from hypertensive rats in terms of morphology and responsiveness to vasoactive mediators. In addition, a decrease in hypertension-related fibrotic and oxidative stress processes was observed in L-NAME-treated rats subjected to ACE oil supplement. Therefore, using a model of AH via nitric oxide depletion, here we demonstrate the beneficial effects of a wild olive oil based upon its vasodilator, antihypertensive, antioxidant, antihypertrophic and antifibrotic properties. We postulate that regular inclusion of ACE oil in the diet can alleviate the vascular remodelling and endothelial dysfunction processes typically found in AH, thus resulting in a significant reduction of BP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据